Drosophila Facility - Publications
List of publications resulted using transgenics generated at Drosophila Facility:
Hegde S, Sreejan A, Gadgil CJ, Ratnaparkhi GS. SUMOylation of Dorsal attenuates Toll/NF-κB signaling. Genetics 2022
Soory A, Ratnaparkhi GS. SUMOylation of Jun fine-tunes the Drosophila gut immune response. PLoS Pathog. 2022
Kapoor A, Padmavathi A, Madhwal S, Mukherjee T. Dual control of dopamine in Drosophila myeloid-like progenitor cell proliferation and regulation of lymph gland growth. EMBO Reports 2022
Goyal M, Tomar A, Madhwal S, Mukherjee T. Blood progenitor redox homeostasis through olfaction derived systemic GABA in hematopoietic growth control in Drosophila. Development 2022
Kumari A, Ghosh A, Kolay S, Raghu P. Septins tune lipid kinase activity and phosphatidylinositol 4,5 bisphosphate turnover during G-protein coupled PLC signaling in vivo. Life Sci Alliance 2022
Nikonova E, Mukherjee A, Kamble K, Barz C, Nongthomba U, Spletter ML. Rbfox1 is required for myofibril development and maintaining fiber type–specific isoform expression in Drosophila muscles. Life Sci Alliance 2022
Varte V, Kairamknoda S, Gupta U, Manjila SB, Mishra A, Salzberg A, Nongthomba U. Neuronal role of taxi is imperative for flight in Drosophila melanogaster. Gene, 2022.
Jahromi SR, Ramesh SR, Finkelstein DI, Haddadi M. α-Synuclein E46K Mutation and Involvement of Oxidative Stress in a Drosophila Model of Parkinson's Disease. Parkinsons Dis. 2021
Pandey M, Bansal S, Bar S, Yadav AK, Sokol NS, Tennessen JM, Kapahi P, Chawla G. miR-125-chinmopathway regulates dietary restriction-dependent enhancement of lifespan in Drosophila. eLife 2021
Nayak P, Kejriwal A and Ratnaparkhi GS SUMOylation of Arginyl tRNA Synthetase Modulates the Drosophila Innate Immune Response. Front. Cell Dev. Biol., 30 September 2021 | https://doi.org/10.3389/fcell.2021.695630
Kizhedathu A, Chhajed P, Yeramala L, Basu DS, Mukherjee T, Vinothkumar KR, Guha A. Duox generated reactive oxygen species activate ATR/Chk1 to induce G2 arrest in Drosophila tracheoblasts. ELife 2021
Ekkaa B, Dhar G, Sahu S, Mishra M, Dash P, Patel RK. Removal of Cr(VI) by silica-titania core-shell nanocomposites: In vivo toxicity assessment of the adsorbent by Drosophila melanogaster. Ceramics International. Volume 47, Issue 13, 1 July 2021, Pages 19079-19089
Basak B, Krishnan H and Raghu P. 2021. Interdomain interactions regulate the localization of a lipid transfer protein at ER-PM contact sites. Biol Open Feb 17.
Trivedi D. 2021. Using CRISPR-Cas9-based genome engineering tools in Drosophila melanogaster. Progress in Molecular Biology and Translational Science. Feb 15.
Santhoshkumar R, Preethish-Kumar V, Mangalaparthi KK, Unni S, Padmanabhan B, Keshava Prasad T. S., Nongthomba U, Atchayaram N, Narayanappa G. A Dominant C150Y Mutation in FHL1 Induces Structural Alterations in LIM2 Domain Causing Protein Aggregation in Human and Drosophila Indirect Flight Muscles. Journal of Molecular Neuroscience, 2021
Wishard R, Jayaram M, Ramesh SR, Nongthomba U. Spatial and temporal requirement of Mlp60A isoforms during muscle development and function in Drosophila melanogaster. BioRXiv 2021
Preethi P, Tomar A, Madhwal S and Mukherjee T, Immune Control of Animal Growth in Homeostasis and Nutritional Stress in Drosophila. Front. Immunol., 2020 https://doi.org/10.3389/fimmu.2020.01528
Madhwal S, Shin M, Kapoor A, Goyal M, Joshi MK, Ur Rehman PM, Gor K, Shim J, Mukherjee T. 2020. Metabolic control of cellular immune-competency by odors in Drosophila. Elife Dec 29;9:e60376. doi: 10.7554/eLife.60376.
Trivedi D, Cm V, Bisht K, Janardan V, Pandit A, Basak B, H S, Ramesh N, Raghu P. A genome engineering resource to uncover principles of cellular organization and tissue architecture by lipid signalling. Elife. 2020 Dec 15;9:e55793. doi: 10.7554/eLife.55793.
Sharma A, Hasan G. Modulation of flight and feeding behaviours requires presynaptic IP3Rs in dopaminergic neurons. Elife. 2020 Nov 6;9:e62297. doi: 10.7554/eLife.62297.
Bakshi A, Sipani R, Ghosh N, Joshi R. Sequential activation of Notch and Grainyhead gives apoptotic competence to Abdominal-B expressing larval neuroblasts in Drosophila Central nervous system. PLoS Genet. 2020 Aug 31;16(8)
Nath VR, Mishra S, Basak B, Trivedi D, Raghu P. Extended synaptotagmin regulates membrane contact site structure and lipid transfer function in vivo. EMBO Rep. 2020 Sep 3;21(9):e50264.
Kaduskar B, Trivedi D, Ratnaparkhi GS. Caspar SUMOylation regulates Drosophila lifespan. MicroPubl Biol. 2020 Aug 2;2020:
Port F, Strein C, Stricker M, Rauscher B, Heigwer F, Zhou J, Beyersdörffer C, Frei J, Hess A, Kern K, Lange L, Langner N, Malamud R, Pavlović B, Rädecke K, Schmitt L, Voos L, Valentini E, Boutros M. A large-scale resource for tissue-specific CRISPR mutagenesis in Drosophila. Elife. 2020 Feb 13
Mehta S, Jayesh Kum, Kumar V, Mishra RKumar. ELYS Regulates Dorsal Dynamics during Development. J Biol Chem. 2020
Sahu S, Mishra M. Hydroxyapatite nanoparticle causes sensory organ defects by targeting the retromer complex in Drosophila melanogaster. NanoImpact, 2020
Dhar G, Bag J, Mishra M. Environmental cue affects the hearing-related behaviors of Drosophila melanogaster by targeting the redox pathways. Environmental Science and Pollution Research, 2020.
Basu U, Balakrishnan SS, Janardan V, Raghu P. A PI4KIIIα protein complex is required for cell viability during Drosophila wing development. Dev Biol. 2020 Jun 15;462(2):208-222.
Ghosh N, Bakshi A, Khandelwal R, Rajan SG, Joshi R. The Hox gene Abdominal-B uses DoublesexF as a cofactor to promote neuroblast apoptosis in the Drosophila central nervous system. Development. 2019 Aug 22;146(16)
Janardan V, Sharma S, Basu U, Raghu P. A Genetic Screen in Drosophila To Identify Novel Regulation of Cell Growth by Phosphoinositide Signaling. G3 (Bethesda). 2019 Nov 8
Dhiman N, Shweta K, Tendulkar S, Deshpande G, Ratnaparkhi GS, Ratnaparkhi A. Drosophila Mon1 constitutes a novel node in the brain-gonad axis that is essential for female germline maturation. Development. 2019 Jul 10;146(13).
Toshniwal AG, Gupta S, Mandal L, Mandal S. ROS Inhibits Cell Growth by Regulating 4EBP and S6K, Independent of TOR, during Development. Dev Cell. 2019 May 6;49(3):473-489.
Das S, Kumar P, Verma A, Maiti TK, Mathew SJ. Myosin heavy chain mutations that cause Freeman-Sheldon syndrome lead to muscle structural and functional defects in Drosophila Dev Biol. 2019 May 15;449(2):90-98.
Mathre S, Reddy KB, Ramya V, Krishnan H, Ghosh A, Raghu P. Functional analysis of the biochemical activity of mammalian phosphatidylinositol 5 phosphate 4-kinase enzymes. Biosci Rep. 2019 Feb 19;39(2).
Sharma S, Mathre S, Ramya V, Shinde D, Raghu P. Phosphatidylinositol 5 Phosphate 4-Kinase Regulates Plasma-Membrane PIP3 Turnover and Insulin Signaling. Cell Rep. 2019 May 14;27(7):1979-1990.e7.
Toda H, Williams JA, Gulledge M, Sehgal A. A sleep-inducing gene, nemuri, links sleep and immune function in Drosophila. Science. 2019 Feb 1;363(6426):509-515.
Steffy B. Manjila, Maria Kuruvilla, Jean-Francois Ferveur, Sanjay P. Sane, Gaiti Hasan. Extended Flight Bouts Require Disinhibition from GABAergic Mushroom Body Neurons. Current Biology. January 2019
Chaplot K, Pimpale L, Ramalingam B, Deivasigamani S, Kamat SS, Ratnaparkhi GS. SOD1 activity threshold and TOR signalling modulate VAP(P58S) aggregation via reactive oxygen species-induced proteasomal degradation in a Drosophila model of amyotrophic lateral sclerosis. Dis Model Mech. 2019
Priyadarsini S, Sahoo M, Sahu S, Jayabalan R, Mishra M. An infection of Enterobacter ludwigii affects development and causes age-dependent neurodegeneration in Drosophila melanogaster. Invertebrate Neuroscience. 2019
Yang G, Humphrey SJ, Murashige DS, Francis D, Wang QP, Cooke KC, Neely G, James DE. RagC phosphorylation autoregulates mTOR complex 1. EMBO J. 2018 Dec 14. pii: e99548. doi: 10.15252/embj.201899548.
Vissers JHA, Froldi F, Schröder J, Papenfuss AT, Cheng LY, Harvey KF. The Scalloped and Nerfin-1 Transcription Factors Cooperate to Maintain Neuronal Cell Fate. Cell Rep. 2018 Nov 6;25(6):1561-1576.
Panda A, Thakur R, Krishnan H, Naik A, Shinde D, Raghu P. Functional analysis of mammalian phospholipase D enzymes.Biosci Rep. 2018 Oct 28. pii: BSR20181690. doi: 10.1042/BSR20181690.
Balakrishnan SS, Basu U, Shinde D, Thakur R, Jaiswal M, Raghu P. Regulation of PI4P levels by PI4KIIIα during G-protein-coupled PLC signaling in Drosophila photoreceptors. J Cell Sci. 2018 Aug 3;131(15).
Ravi P, Trivedi D, Hasan G. FMRFa receptor stimulated Ca2+ signals alter the activity of flight modulating central dopaminergic neurons in Drosophila melanogaster. PLoS Genet. 2018 Aug 15;14(8)
Shukla V, Dhiman N, Nayak P, Dahanukar N, Deshpande G, Ratnaparkhi GS. Stonewall and Brickwall: Two Partially Redundant Determinants Required for the Maintenance of Female Germline in Drosophila. G3 (Bethesda). 2018 May 31;8(6):2027-2041.
Bakthavachalu B, Huelsmeier J, Sudhakaran IP, Hillebrand J, Singh A, Petrauskas A, Thiagarajan D, Sankaranarayanan M, Mizoue L, Anderson EN, Pandey UB, Ross E, VijayRaghavan K, Parker R, Ramaswami M. RNP-Granule Assembly via Ataxin-2 Disordered Domains Is Required for Long-Term Memory and Neurodegeneration. Neuron. 2018 May 16;98(4):754-766.
Kizhedathu A, Bagul AV, Guha A. Negative regulation of G2-M by ATR (mei-41)/Chk1(Grapes) facilitates tracheoblast growth and tracheal hypertrophy in Drosophila. Elife. 2018 Apr 16;7
Bohra AA, Kallman BR, Reichert H, VijayRaghavan K. Identification of a Single Pair of Interneurons for Bitter Taste Processing in the Drosophila Brain.Curr Biol. 2018 Mar 19;28(6):847-858.
Gowda SBM, Paranjpe PD, Reddy OV, Thiagarajan D, Palliyil S, Reichert H, VijayRaghavan K.GABAergic inhibition of leg motoneurons is required for normal walking behavior in freely moving Drosophila. Proc Natl Acad Sci U S A. 2018 Feb 27;115(9)
Yadav S, Thakur R, Georgiev P, Deivasigamani S, Krishnan H, Ratnaparkhi G, Raghu P. RDGBα localization and function at membrane contact sites is regulated by FFAT-VAP interactions. J Cell Sci. 2018 Jan 8;131(1).
Ashe S, Malhotra V, Raghu P. Protein kinase D regulates metabolism and growth by controlling secretion of insulin like peptide. Dev Biol. 2017 Dec 13
Khandelwal R, Sipani R, Govinda Rajan S, Kumar R, Joshi R. Combinatorial action of Grainyhead, Extradenticle and Notch in regulating Hox mediated apoptosis in Drosophila larval CNS. PLoS Genet. 2017 Oct 12;13(10):e1007043.
Chaturvedi D, Reichert H, Gunage RD, K VijayRaghavan. Identification and functional characterization of muscle satellite cells in Drosophila. Elife. 2017 Oct 26;6.
Kuklin EA, Alkins S, Bakthavachalu B, Genco MC, Sudhakaran I, Raghavan KV, Ramaswami M, Griffith LC. The long 3'UTR mRNA of CaMKII is essential for translation-dependent plasticity of spontaneous release in Drosophila melanogaster. J Neurosci. 2017 Sep 27.
Kumari K, Trivedi D, Toscano S, Sharma S, Kolay S, Raghu P. Phosphatidylinositol 5-phosphate 4-kinase regulates early endosomal dynamics during clathrin-mediated endocytosis. JCS May 16 2017.
Richhariya S, Jayakumar S, Abruzzi K, Rosbash M, and Hasan G. A pupal transcriptomic screen identifies Ral as a target of store-operated calcium entry in Drosophila neurons. Sci Rep. 2017 Feb 14
Pathak T, Trivedi D, Hasan G. CRISPR-Cas Induced Mutants Identify a Requirement for dSTIM in Larval Dopaminergic Cells of Drosophila melanogaster. G3 (Bethesda) 2017 Jan 27. pii: g3.116.038539.
Thakur R, Panda A, Coessens E, Raj N, Yadav S, Balakrishnan S, Zhang Q, Georgiev P, Basak B, Pasricha R, Wakelam MJ, Ktistakis NT, Raghu P. Phospholipase D activity couples plasma membrane endocytosis with retromer dependent recycling. Elife. 2016 Nov 16;5. pii: e18515.
Jayakumar S, Richhariya S, Reddy OV, Texada MJ, Hasan G. Drosophila larval to pupal switch under nutrient stress requires IP3R/Ca(2+) signalling in glutamatergic interneurons. Elife. 2016 Aug 5;5. pii: e17495.
Deb, B.K., Pathak, T. and Hasan, G. Store-independent modulation of Ca2+ entry through Orai by Septin 7 (2016). Nat. Comm. doi:10.1038/ncomms11751
Syed DS, Gowda SB, Reddy OV, Reichert H, VijayRaghavan K. Glial and neuronal Semaphorin signaling instruct the development of a functional myotopic map for Drosophila walking (2016). Elife. Feb 29;5. pii: e11572.
Sarov M, Barz C, Jambor H, Hein MY, Schmied C, Suchold D, Stender B, Janosch S, KJ Vinay Vikas, Krishnan RT, Krishnamoorthy A, Ferreira IR, Ejsmont RK, Finkl K, Hasse S, Kämpfer P, Plewka N, Vinis E, Schloissnig S, Knust E, Hartenstein V, Mann M, Ramaswami M, VijayRaghavan K, Tomancak P, Schnorrer F. A genome-wide resource for the analysis of protein localisation in Drosophila (2016). Elife. Feb 20;5. pii: e12068.
Kumar R, Chotaliya M, Vuppala S, Auradkar A, Palasamudrum K, Joshi R. Role of Homothorax in region specific regulation of Deformed in embryonic neuroblasts. Mech Dev. 2015 Nov;138 Pt 2:190-7.
Pathak, T., Agrawal, T., Richhariya, S., Sadaf, S. and Hasan, G. Store-Operated Calcium Entry through Orai Is Required for Transcriptional Maturation of the Flight Circuit in Drosophila (2015). J Neurosci,7 October 2015, 35(40): 13784-13799; doi: 10.1523/JNEUROSCI.1680-15.2015, F1000Prime
Yadav S, Garner K, Georgiev P, Li M, Gomez-Espinosa E, Panda A, Mathre S, Okkenhaug H, Cockcroft S, Raghu P. RDGBα, a PI-PA transfer protein regulates G-protein coupled PtdIns(4,5)P2 signalling during Drosophila phototransduction. J Cell Sci. 2015 Jul 22. pii: jcs.173476.
Chakrabarti, P., Kolay, S., Yadav, S, Kamalesh Kumari, K., Nair, A., Trivedi, D and Raghu, P. A dPIP5K dependent pool of phosphatidylinositol 4,5 bisphosphate (PIP2) is required for G-protein coupled signal transduction in Drosophila photoreceptors. PLoS Genet. 2015 Jan 29;11(1)
Sonia Sen, Deshou Cao, Ramveer Choudhary, Silvia Biagini, Jing Wang, HeinrichReichert, K VijayRaghavan. Genetic transformation of structural and functional circuitry rewires the Drosophila brain December 29, 2014 eLife 2014;3
Moumita Chakrabotry; Blesson K Paul; Tanmoyita Nayak; Aniruddha Das; Nihar R Jana; Supriya Bhutani. "The E3 ligase ube3a is required for learning in Drosophila melanogaster". Biochemical and Biophysical Research Communications (BBRC)
Agrawal, T., Sadaf, S. and Hasan, G. (2013). A Genetic RNAi screen for IP_3 /Ca^2+ coupled GPCRs in Drosophila identifies the PdfR as a regulator of insect flight. Plos Genet.
Chakraborty, S and Hasan, G. (2012). Functional complementation of Drosophila itpr mutants by Rat IP_3 R1. J. Neurogenet 26: 328-337
Sadananda, A., Hamid, R., Doodhi, H., Ghosal, D., Girotra, M., Jana, S. C., and Ray, K. (2012) Interaction with a kinesin-2 tail propels choline acetyltransferase flow towards synapse. Traffic, 13:979-991.
K.G. Guruharsha, Robert A. Obar, Julian Mintseris, K. Aishwarya, R.T. Krishnan, K. VijayRaghavan & Spyros Artavanis-Tsakonas (2012) Drosophila Protein interaction Map (DPiM), Fly, 6:4, 246-253
Supriya Bhutani, Aniruddha Das, Megha Maheshwari, Subhash Lakhotia and Nihar Ranjan Jana. “Dysregulation of core components of SCF complex in poly-glutamine disorders”. Cell Death and Disease: 3:e428 (2012)
K.G. Guruharsha, Jean-Franc¸ ois Rual, Bo Zhai, Julian Mintseris,Pujita Vaidya, Namita Vaidya, Chapman Beekman, Christina Wong, David Y. Rhee, Odise Cenaj, Emily McKillip, Saumini Shah, Mark Stapleton, Kenneth H. Wan,Charles Yu, Bayan Parsa, Joseph W. Carlson, Xiao Chen, Bhaveen Kapadia, K. VijayRaghavan, Steven P. Gygi, Susan E. Celniker, Robert A. Obar and Spyros Artavanis-Tsakonas1. A Protein Complex Network of Drosophila melanogaster. Cell 147, 690–703, October 28
Agrawal, N., Venkiteswaran, G., Sadaf, S., Padmanabhan, N., Banerjee, S and Hasan, G. Inositol 1,4,5-trisphosphate receptor and dSTIM function in Drosophila insulin producing neurons regulates systemic intracellular calcium homeostasis and flight. J. Neurosci, 30, 1301-1313.
Agrawal, N., Padmanabhan, N and Hasan G. Inositol 1,4,5 - trisphosphate Receptor Function in /Drosophila/ Insulin Producing Cells. PLoS One, 4(8): e6652 doi:10.1371/journal.pone.0006652.
Venkiteswaran, G and Hasan, G. Intracellular calcium signaling and store operated Ca^2+ entry are required in Drosophila neurons for flight. Proc. Natl. Acad. Sci. USA,USA, 106, 10326-10331.