Pathways of clathrin-independent endocytosis.
|Pathways of clathrin-independent endocytosis.
|Year of Publication
|Mayor S, Pagano RE
|Nat Rev Mol Cell Biol
|Animals, Bacteria, Biological Transport, Active, Clathrin, Endocytosis, Eukaryotic Cells, Humans, Virus Internalization, Viruses
There are numerous ways that endocytic cargo molecules may be internalized from the surface of eukaryotic cells. In addition to the classical clathrin-dependent mechanism of endocytosis, several pathways that do not use a clathrin coat are emerging. These pathways transport a diverse array of cargoes and are sometimes hijacked by bacteria and viruses to gain access to the host cell. Here, we review our current understanding of various clathrin-independent mechanisms of endocytosis and propose a classification scheme to help organize the data in this complex and evolving field.
|Nat. Rev. Mol. Cell Biol.
|/ / Wellcome Trust / United Kingdom