Building endocytic pits without clathrin.
|Title||Building endocytic pits without clathrin.|
|Publication Type||Journal Article|
|Year of Publication||2015|
|Authors||Johannes L, Parton RG, Bassereau P, Mayor S|
|Journal||Nat Rev Mol Cell Biol|
|Date Published||2015 May|
|Keywords||Actins, Animals, Cell Membrane, Clathrin, Endocytosis, Humans, Lectins, Metabolic Networks and Pathways|
How endocytic pits are built in clathrin- and caveolin-independent endocytosis still remains poorly understood. Recent insight suggests that different forms of clathrin-independent endocytosis might involve the actin-driven focusing of membrane constituents, the lectin-glycosphingolipid-dependent construction of endocytic nanoenvironments, and Bin-Amphiphysin-Rvs (BAR) domain proteins serving as scaffolding modules. We discuss the need for different types of internalization processes in the context of diverse cellular functions, the existence of clathrin-independent mechanisms of cargo recruitment and membrane bending from a biological and physical perspective, and finally propose a generic scheme for the formation of clathrin-independent endocytic pits.
|Alternate Journal||Nat. Rev. Mol. Cell Biol.|