Building endocytic pits without clathrin.
| Title | Building endocytic pits without clathrin. |
| Publication Type | Journal Article |
| Year of Publication | 2015 |
| Authors | Johannes L, Parton RG, Bassereau P, Mayor S |
| Journal | Nat Rev Mol Cell Biol |
| Volume | 16 |
| Issue | 5 |
| Pagination | 311-21 |
| Date Published | 2015 May |
| ISSN | 1471-0080 |
| Keywords | Actins, Animals, Cell Membrane, Clathrin, Endocytosis, Humans, Lectins, Metabolic Networks and Pathways |
| Abstract | How endocytic pits are built in clathrin- and caveolin-independent endocytosis still remains poorly understood. Recent insight suggests that different forms of clathrin-independent endocytosis might involve the actin-driven focusing of membrane constituents, the lectin-glycosphingolipid-dependent construction of endocytic nanoenvironments, and Bin-Amphiphysin-Rvs (BAR) domain proteins serving as scaffolding modules. We discuss the need for different types of internalization processes in the context of diverse cellular functions, the existence of clathrin-independent mechanisms of cargo recruitment and membrane bending from a biological and physical perspective, and finally propose a generic scheme for the formation of clathrin-independent endocytic pits. |
| DOI | 10.1038/nrm3968 |
| Alternate Journal | Nat. Rev. Mol. Cell Biol. |
| PubMed ID | 25857812 |