Publications

 

Ibrahim Umar, Shah-E-Jahan Gulzar, Varadharajan Sundaramurthy. "M. tuberculosis surface sulfoglycolipid SL-1 activates the mechanosensitive channel TRPV4 to enhance lysosomal biogenesis and exocytosis in macrophages". Molecular Biology of the Cell, mbc. E24-12-0560, April 30 2025 https://doi.org/10.1091/mbc.E24-12-0560

Mangaiarkarasi S Asokan, Roshni Florina Joan, Sudhir Babji, Girish Dayma, Prajitha Nadukkandy, Vinutha Subrahmanyam, Archana Pandey, Girish Malagi, Pooja Arya, Vibhuti Mahajan, Jayateerth Bhavikatti, Ketakee Pawar, Aishwarya Thorat, Priyanki Shah, Ramakrishna B Goud, Bishnudeo Roy, Shon Rajukutty, Sushil Immanuel, Dhiraj Agarwal, Sankhanil Saha, Akshatha Shivaraj, Patricia Panikulam, Rajeshwari Shome, Shah-E-Jahan Gulzar, Anusmrithi U Sharma, Ajinkya Naik, Shruti Talashi, Madhuri Belekar, Ritu Yadav, Poornima Khude, V Mamatha, Sudarshan Shivalingaiah, Urmila Deshmukh, Chinmayee Bhise, Manjiri Joshi, Leeberk Raja Inbaraj, Sindhulina Chandrasingh, Aurnab Ghose, Colin Jamora, Anandi S Karumbati, Varadharajan Sundaramurthy, Avita Johnson, Naveen Ramesh, Nirutha Chetan, Chaitra Parthiban, Asma Ahmed, Srabanti Rakshit, Vasista Adiga, George D'souza, Vinay Rale, Carolin Elizabeth George, Jacob John, Anand Kawade, Akanksha Chaturvedi, Anu Raghunathan, Mary Dias, Anand Bhosale, Padinjat Raghu, LS Shashidhara, Annapurna Vyakarnam, Vineeta Bal, Gagandeep Kang, Satyajit Mayor. "Immunogenicity of SARS-CoV-2 vaccines BBV152 (COVAXIN®) and ChAdOx1 nCoV-19 (COVISHIELD™) in seronegative and seropositive individuals in India: a multicentre, nonrandomised". The Lancet Regional Health-Southeast Asia, February 27 2024 https://doi.org/10.1016/j.lansea.2024.100361

Colin Jamora Tanay Bhatt, Binita Dam, Sneha Uday Khedkar, Sahil Lall, Subhashini Pandey, Sunny Kataria, Johan Ajnabi, Shah-E-Jahan Gulzar, Paul M. Dias, Morris Waskar, Janhavi Raut, Varadharajan Sundaramurthy, Praveen Kumar Vemula, Naresh Ghatlia, Amitabha Majumdar. "Niacinamide enhances cathelicidin mediated SARS-CoV-2 membrane disruption". Frontiers in Immunology, November 8 2023 https://doi.org/10.3389/fimmu.2023.1255478
 
Jigme Wangchuk, Aakriti Singh, Shalini Shakthivel, Dhruv Sheth, Varadharajan Sundaramurthy, Anandi S Karumbati, Chris Miller, Keith Moore, Saurabh Ratilal Patil, Saiprasad Vilas Patil, Hanmant Barkate. "In Vitro Virucidal Assays to Evaluate the Antiviral Efficacy of Nitric Oxide Nasal Spray Against Different Sars-Cov-2 Variants". SSRN 4532325 August 17 2023 https://doi.org/10.2139/ssrn.4532325
 

Kushi Anand and Varadharajan Sundaramurthy. "Mycobacterial lipids in the host–pathogen interface: roles in pathogenesis and host immune response". Biology of Mycobacterial Lipids, Developments in Microbiology, 2022, Pages 51-82 https://doi.org/10.1016/B978-0-323-91948-7.00005-1

Aparajita Lahree, Sara de Jesus Santos Baptista, Sofia Marques, Veronika Perschin, Vanessa Zuzarte-Luı ́s, Manisha Goel, Hadi Hasan Choudhary, Satish Mishra, Christian Stigloher, Marino Zerial, Varadharajan Sundaramurthy and Maria M. Mota.  Active APPL1 sequestration by Plasmodium favors liver-stage development.  Cell Reports 39, 110886, May 31, 2022 https://doi.org/10.1016/j.celrep.2022.110886

Sonali Setua, Francisco J. Enguita, Ângelo Ferreira Chora, Harish Ranga-prasad, Aparajita Lahree, Sofia Marques, Varadharajan Sundaramurthy and Maria M. Mota. Disrupting Plasmodium UIS3–host LC3 interaction with a small molecule causes parasite elimination from host cells. Communication Biology, 2020 3:688, https://doi.org/10.1038/s42003-020-01422-1

Chaitra Prabhakara , Rashmi Godbole , Parijat Sil , Sowmya Jahnavi , Shah-E-Jahan Gulzar , Thomas S van Zanten , Dhruv Sheth , Neeraja Subhash , Anchal Chandra , Akshatha Shivaraj , Patricia Panikulam , Ibrahim U , Vijay Kumar Nuthakki , Theja Parassini Puthiyapurayil , Riyaz Ahmed , Ashaq Hussain Najar , Sai Manoz Lingamallu , Snigdhadev Das , Bhagyashri Mahajan , Praveen Vemula , Sandip B Bharate , Parvinder Pal Singh , Ram Vishwakarma , Arjun Guha , Varadharajan Sundaramurthy* , Satyajit Mayor*. Strategies to target SARS-CoV-2 entry and infection using dual mechanisms of inhibition by acidification inhibitors. PLoS Pathog. 2021;17(7):e1009706. Published 2021 Jul 12. doi:10.1371/journal.ppat.1009706 (*corresponding authors)

Subhash N, Sundaramurthy V. Advances in host-based screening for compounds with intracellular anti-mycobacterial activity. Cell Microbiol. 2021;23(7):e13337. doi:10.1111/cmi.13337

Sachdeva K and Sundaramurthy V. The Interplay of Host Lysosomes and Intracellular Pathogens. Front. Cell. Infect. Microbiol. 2020. 10:595502. doi: 10.3389/fcimb.2020.595502

Saurabh Kaushik, Manohara Mahadeva, Kandhasamy Durai Murugan, Varadharajan Sundaramurthy and Gautam Vivek Soni, "Measurement of Alcohol-Dependent Physiological Changes in Red Blood Cells Using Resistive Pulse Sensing". ACS Sens. 2020, 5, 12, 3892–3901, November 18, https://doi.org/10.1021/acssensors.0c01302

Pradeep A. Subramani, Neha Vartak-Sharma, Seetha Sreekumar, Pallavi Mathur, Bhavana Nayer, Sushrut Dakhore, Sowmya K. Basavanna, Devaiah M. Kalappa, Ramya V. Krishnamurthy, Benudhar Mukhi, Priyasha Mishra, Noriko Yoshida, Susanta Kumar Ghosh, Radhakrishan Shandil, Shridhar Narayanan, Brice Campo, Kouichi Hasegawa, Anupkumar R. Anvikar, Neena Valecha & Varadharajan Sundaramurthy. Plasmodium vivax liver stage assay platforms using Indian clinical isolates. Malaria J. 2020, 19, 214.  https://doi.org/10.1186/s12936-020-03284-8

Sachdeva, K., Goel, M., & Sundaramurthy, V.  Heterogeneity in the endocytic capacity of individual macrophage in a population determines its subsequent phagocytosis, infectivity and sub‐cellular trafficking. Traffic. 2020.  doi:10.1111/tra.12752

Kuldeep Sachdeva, Manisha Goel, Malvika Sudhakar, Mansi Mehta, Rajmani Raju, Karthik Raman, Amit Singh, Varadharajan Sundaramurthy. Mycobacterium tuberculosis (Mtb) lipid–mediated lysosomal rewiring in infected macrophages modulates intracellular Mtb trafficking and survival. J. Biol. Chem. 2020, May 18. doi: 10.1074/jbc.RA120.012809

Balasubramanian L, Zuzarte-Luís V, Syed T, Mullick D, Deb S, Ranga-Prasad H, Meissner J, Almeida A, Furstenhaupt T, Siddiqi K, Prudêncio M, Rodrigues CMP, Mota M and Sundaramurthy V.  Association of Plasmodium berghei With the Apical Domain of Hepatocytes Is Necessary for the Parasite's Liver Stage Development. Front. Cell. Infect. Microbiol. 2020, 9:451. doi: 10.3389/fcimb.2019.00451

Evans RJ, Sundaramurthy V* and Frickel EM*. The Interplay of Host Autophagy and Eukaryotic Pathogens. Front. Cell Dev. Biol. 2018, 6:118. doi: 10.3389/fcell.2018.00118 (* corresponding authors)

Sundaramurthy V*, Korf H, Singla A, Scherr N, Nguyen L, Ferrari G, Landmann R, Huygen K, Pieters J.  Survival of Mycobacterium tuberculosis and Mycobacterium bovis BCG in lysosomes in vivo.  Microbes and Infection. 2017 Nov;19(11):515-526.  (* corresponding author)

Sundaramurthy, V. Barsacchi, R. Chernykh, M. Stoter, M. Tomschke, N. Bickle, M. Kalaidzidis, Y. and Zerial, M. "Deducing the mechanism of action of compounds identified in phenotypic screens by integrating their multiparametric profiles with a reference genetic screen". Nature protocols, 2014, 9, 474-90.

Varadharajan Sundaramurthy, Rico Barsacchi, Nikolay Samusik, Giovanni Marsico, Jerome Gilleron, Inna Kalaidzidis, Felix Meyenhofer, Marc Bickle, Yannis Kalaidzidis and Marino Zerial. Integration of chemical and genome-wide siRNA multi-parametric profiles identifies triggers of intracellular mycobacterial killing. Cell Host and Microbe, 2013, 13, 129-142, February 13.

Rajesh Jayachandran*, Varadharajan Sundaramurthy*, Benoit Combaluzier, Philipp Muller, Hannelie Korf, Kris Huygen, Toru Miyazaki, Imke Albrecht, Jan Massner and Jean Pieters. Survival of Mycobacteria in Macrophages is Mediated by Coronin 1 Dependent Activation of Calcineurin. Cell, 2007, 130, 37-50, July 13. (* equal contribution).

Varadharajan Sundaramurthy and Jean Pieters. Interactions of pathogenic mycobacteria with host macrophages. Microbes and Infection, 2007, Nov-Dec;9(14-15):1671-9.

S. Varadharajan, B. K. Chandrasekhar Sagar, P. N. Rangarajan and G. Padmanaban. "Localization of Ferrochelatase in Plasmodium falciparum". Biochem. J. 384, 429-36, 2004.

S. Varadharajan, S. Dhanasekharan, Z. Q. Bonday, P. N. Rangarajan and G. Padmanaban. "Involvement of d-Aminolaevulinate synthase encoded by parasite gene in de novo haem synthesis by Plasmodium falciparum". Biochem. J. 367, 321-327, 2002.