The ubiquitous nanocluster: A molecular scale organizing principle that governs cellular information flow.
| Title | The ubiquitous nanocluster: A molecular scale organizing principle that governs cellular information flow. |
| Publication Type | Journal Article |
| Year of Publication | 2024 |
| Authors | Garcia-Parajo MF, Mayor S |
| Journal | Curr Opin Cell Biol |
| Volume | 86 |
| Pagination | 102285 |
| Date Published | 2023 Dec 05 |
| ISSN | 1879-0410 |
| Abstract | The language of biology at the scale of the cell is constituted of alphabets represented by biomolecules. These are stitched together in a variety of ways to create meaning. We argue that the phrases of this language are nanoscale molecular assemblies or nano-hubs for the purpose of information flow. At the cell surface information is sensed and processed via membrane receptors, often configured as multimers. These nano-assemblies serve as receiver nano-hubs, which are flexibly configured with additional nano-hubs that we term modifiers and transducers. This framework serves to process information that is transmitted for execution inside the cell. Here, we explore some examples about how nano-hubs are built and how they may contribute to cellular information flow. |
| DOI | 10.1016/j.ceb.2023.102285 |
| Alternate Journal | Curr Opin Cell Biol |
| PubMed ID | 38056142 |