TitleThe ubiquitous nanocluster: A molecular scale organizing principle that governs cellular information flow.
Publication TypeJournal Article
Year of Publication2024
AuthorsGarcia-Parajo MF, Mayor S
JournalCurr Opin Cell Biol
Date Published2023 Dec 05

The language of biology at the scale of the cell is constituted of alphabets represented by biomolecules. These are stitched together in a variety of ways to create meaning. We argue that the phrases of this language are nanoscale molecular assemblies or nano-hubs for the purpose of information flow. At the cell surface information is sensed and processed via membrane receptors, often configured as multimers. These nano-assemblies serve as receiver nano-hubs, which are flexibly configured with additional nano-hubs that we term modifiers and transducers. This framework serves to process information that is transmitted for execution inside the cell. Here, we explore some examples about how nano-hubs are built and how they may contribute to cellular information flow.

Alternate JournalCurr Opin Cell Biol
PubMed ID38056142