TitleTopology prediction of insect olfactory receptors.
Publication TypeJournal Article
Year of Publication2019
AuthorsTiwari V, Karpe SD, Sowdhamini R
JournalCurr Opin Struct Biol
Date Published2019 Jun 21

Olfactory receptors are important transmembrane proteins that enable organisms to perceive odours and react to them. Structural understanding of insect olfactory receptors is scarce. In this review, we discuss different transmembrane helix prediction methods, consensus methods, topology prediction methods which can enable topology prediction of these proteins. We discuss the current success rates by applying the algorithms on few G-protein coupled receptors of known structure and olfactory receptor sequences and outstanding challenges. Finally, we discuss the impact of topology prediction on biology and modeling of ORs.

Alternate JournalCurr. Opin. Struct. Biol.
PubMed ID31233963