A sex difference in the response of the rodent postsynaptic density to synGAP haploinsufficiency
| Title | A sex difference in the response of the rodent postsynaptic density to synGAP haploinsufficiency |
| Publication Type | Journal Article |
| Year of Publication | 2020 |
| Authors | Mastro TL, Preza A, Basu S, Chattarji S, Till SM, Kind PC, Kennedy MB |
| Journal | Elife |
| Start Page | e52656 |
| Date Published | 01/2020 |
| Abstract | SynGAP is a postsynaptic density (PSD) protein that binds to PDZ domains of the scaffold protein PSD-95. We previously reported that heterozygous deletion of Syngap1 in mice is correlated with increased steady-state levels of other key PSD proteins that bind PSD-95, although the level of PSD-95 remains constant (Walkup et al., 2016). For example, the ratio to PSD-95 of Transmembrane AMPA-Receptor-associated Proteins (TARPs), which mediate binding of AMPA-type glutamate receptors to PSD-95, was increased in young Syngap1+/-mice. Here we show that only females and not males show a highly significant correlation between an increase in TARP and a decrease in synGAP in the PSDs of Syngap1+/-rodents. The data reveal a sex difference in the adaptation of the PSD scaffold to synGAP haploinsufficiency. |
| DOI | 10.7554/eLife.52656 |