RNA diversification by a self-reproducing ribozyme revealed by deep sequencing and kinetic modelling.
|Title||RNA diversification by a self-reproducing ribozyme revealed by deep sequencing and kinetic modelling.|
|Publication Type||Journal Article|
|Year of Publication||2021|
|Authors||Jeancolas C, Matsubara YJ, Vybornyi M, Lambert CN, Blokhuis A, Alline T, Griffiths AD, Ameta S, Krishna S, Nghe P|
|Journal||Chem Commun (Camb)|
|Date Published||2021 Jul 08|
We demonstrate that a recombinase ribozyme achieves multiple functions in the same reaction network: self-reproduction, iterative elongation and circularization of other RNAs, leading to synthesis of diverse products predicted by a kinetic model. This shows that key mechanisms can be integrated and controlled toward Darwinian evolution in RNA reaction networks.
|Alternate Journal||Chem Commun (Camb)|