TitleRNA diversification by a self-reproducing ribozyme revealed by deep sequencing and kinetic modelling.
Publication TypeJournal Article
Year of Publication2021
AuthorsJeancolas C, Matsubara YJ, Vybornyi M, Lambert CN, Blokhuis A, Alline T, Griffiths AD, Ameta S, Krishna S, Nghe P
JournalChem Commun (Camb)
Date Published2021 Jul 08

We demonstrate that a recombinase ribozyme achieves multiple functions in the same reaction network: self-reproduction, iterative elongation and circularization of other RNAs, leading to synthesis of diverse products predicted by a kinetic model. This shows that key mechanisms can be integrated and controlled toward Darwinian evolution in RNA reaction networks.

Alternate JournalChem Commun (Camb)
PubMed ID34235521