Regulation of neuronal physiology by Ca2+ release through the IP3R
|Title||Regulation of neuronal physiology by Ca2+ release through the IP3R|
|Publication Type||Journal Article|
|Year of Publication||2020|
|Authors||Hasan G, Sharma A|
|Journal||Current Opinion in Physiology|
Identification of mutations in the gene encoding the inositol 1,4,5-trisphosphate receptor Type 1 (IP3R1) as causative for Spinocerebellar Ataxia 15, 29 and Gillespie Syndrome emphasize the importance of understanding how the IP3R impacts neuronal function and physiology. Here we discuss how cellular changes due to IP3 mediated Ca2+release affect systemic physiology in Drosophila and mouse. The relevance of these findings to recently identified human neurological conditions are also discussed.