Progressing Towards a Human-Centric Approach in Cancer Research.
| Title | Progressing Towards a Human-Centric Approach in Cancer Research. |
| Publication Type | Journal Article |
| Year of Publication | 2022 |
| Authors | Parekh A, Das S, Das CK, Mandal M |
| Journal | Front Oncol |
| Volume | 12 |
| Pagination | 896633 |
| Date Published | 2022 |
| ISSN | 2234-943X |
| Abstract | Despite the advancement in research methodologies and technologies for cancer research, there is a high rate of anti-cancer drug attrition. In this review, we discuss different conventional and modern approaches in cancer research and how human-centric models can improve on the voids conferred by more traditional animal-centric models, thereby offering a more reliable platform for drug discovery. Advanced three-dimensional cell culture methodologies, along with computational analysis form the core of human-centric cancer research. This can provide a holistic understanding of the research problems and help design specific and accurate experiments that could lead to the development of better cancer therapeutics. Here, we propose a new human-centric research roadmap that promises to provide a better platform for cancer research and drug discovery. |
| DOI | 10.3389/fonc.2022.896633 |
| Alternate Journal | Front Oncol |
| PubMed ID | 35928861 |
| PubMed Central ID | PMC9343698 |