TitleProgressing Towards a Human-Centric Approach in Cancer Research.
Publication TypeJournal Article
Year of Publication2022
AuthorsParekh A, Das S, Das CK, Mandal M
JournalFront Oncol
Date Published2022

Despite the advancement in research methodologies and technologies for cancer research, there is a high rate of anti-cancer drug attrition. In this review, we discuss different conventional and modern approaches in cancer research and how human-centric models can improve on the voids conferred by more traditional animal-centric models, thereby offering a more reliable platform for drug discovery. Advanced three-dimensional cell culture methodologies, along with computational analysis form the core of human-centric cancer research. This can provide a holistic understanding of the research problems and help design specific and accurate experiments that could lead to the development of better cancer therapeutics. Here, we propose a new human-centric research roadmap that promises to provide a better platform for cancer research and drug discovery.

Alternate JournalFront Oncol
PubMed ID35928861
PubMed Central IDPMC9343698