TitlePhysiology and Therapeutic Potential of SK, H, and M Medium AfterHyperPolarization Ion Channels.
Publication TypeJournal Article
Year of Publication2021
AuthorsDwivedi D, Bhalla US
JournalFront Mol Neurosci
Date Published2021

SK, HCN, and M channels are medium afterhyperpolarization (mAHP)-mediating ion channels. The three channels co-express in various brain regions, and their collective action strongly influences cellular excitability. However, significant diversity exists in the expression of channel isoforms in distinct brain regions and various subcellular compartments, which contributes to an equally diverse set of specific neuronal functions. The current review emphasizes the collective behavior of the three classes of mAHP channels and discusses how these channels function together although they play specialized roles. We discuss the biophysical properties of these channels, signaling pathways that influence the activity of the three mAHP channels, various chemical modulators that alter channel activity and their therapeutic potential in treating various neurological anomalies. Additionally, we discuss the role of mAHP channels in the pathophysiology of various neurological diseases and how their modulation can alleviate some of the symptoms.

Alternate JournalFront Mol Neurosci
PubMed ID34149352
PubMed Central IDPMC8209339