TitlePhysical principles of membrane remodelling during cell mechanoadaptation.
Publication TypeJournal Article
Year of Publication2015
AuthorsKosmalska AJoanna, Casares L, Elosegui-Artola A, Thottacherry JJose, Moreno-Vicente R, González-Tarragó V, del Pozo MÁngel, Mayor S, Arroyo M, Navajas D, Trepat X, Gauthier NC, Roca-Cusachs P
JournalNat Commun
Date Published2015

Biological processes in any physiological environment involve changes in cell shape, which must be accommodated by their physical envelope--the bilayer membrane. However, the fundamental biophysical principles by which the cell membrane allows for and responds to shape changes remain unclear. Here we show that the 3D remodelling of the membrane in response to a broad diversity of physiological perturbations can be explained by a purely mechanical process. This process is passive, local, almost instantaneous, before any active remodelling and generates different types of membrane invaginations that can repeatedly store and release large fractions of the cell membrane. We further demonstrate that the shape of those invaginations is determined by the minimum elastic and adhesive energy required to store both membrane area and liquid volume at the cell-substrate interface. Once formed, cells reabsorb the invaginations through an active process with duration of the order of minutes.

Alternate JournalNat Commun
PubMed ID26073653
PubMed Central IDPMC4490354
Grant List242993 / / European Research Council / International