Organelle acidification: an ancient cellular leak detector.
| Title | Organelle acidification: an ancient cellular leak detector. |
| Publication Type | Journal Article |
| Year of Publication | 2017 |
| Authors | Thattai M |
| Journal | BMC Biol |
| Volume | 15 |
| Issue | 1 |
| Pagination | 51 |
| Date Published | 2017 Jun 26 |
| ISSN | 1741-7007 |
| Abstract | Intracellular membrane-bounded organelles of eukaryotic cells transiently contact the extracellular environment during endocytosis and secretion. Such contacts must be precisely timed to prevent leakage of cargo. I argue that early eukaryotes evolved organelle acidification as a way to detect and prevent leakage. |
| DOI | 10.1186/s12915-017-0395-1 |
| Alternate Journal | BMC Biol. |
| PubMed ID | 28651577 |
| PubMed Central ID | PMC5485493 |