Organelle acidification: an ancient cellular leak detector.
Title | Organelle acidification: an ancient cellular leak detector. |
Publication Type | Journal Article |
Year of Publication | 2017 |
Authors | Thattai M |
Journal | BMC Biol |
Volume | 15 |
Issue | 1 |
Pagination | 51 |
Date Published | 2017 Jun 26 |
ISSN | 1741-7007 |
Abstract | Intracellular membrane-bounded organelles of eukaryotic cells transiently contact the extracellular environment during endocytosis and secretion. Such contacts must be precisely timed to prevent leakage of cargo. I argue that early eukaryotes evolved organelle acidification as a way to detect and prevent leakage. |
DOI | 10.1186/s12915-017-0395-1 |
Alternate Journal | BMC Biol. |
PubMed ID | 28651577 |
PubMed Central ID | PMC5485493 |