TitleKey challenges for the creation and maintenance of specialist protein resources.
Publication TypeJournal Article
Year of Publication2015
AuthorsHolliday GL, Bairoch A, Bagos PG, Chatonnet A, Craik DJ, Finn RD, Henrissat B, Landsman D, Manning G, Nagano N, O'Donovan C, Pruitt KD, Rawlings ND, Saier M, Sowdhamini R, Spedding M, Srinivasan N, Vriend G, Babbitt PC, Bateman A
Date Published2015 Jun

As the volume of data relating to proteins increases, researchers rely more and more on the analysis of published data, thus increasing the importance of good access to these data that vary from the supplemental material of individual articles, all the way to major reference databases with professional staff and long-term funding. Specialist protein resources fill an important middle ground, providing interactive web interfaces to their databases for a focused topic or family of proteins, using specialized approaches that are not feasible in the major reference databases. Many are labors of love, run by a single lab with little or no dedicated funding and there are many challenges to building and maintaining them. This perspective arose from a meeting of several specialist protein resources and major reference databases held at the Wellcome Trust Genome Campus (Cambridge, UK) on August 11 and 12, 2014. During this meeting some common key challenges involved in creating and maintaining such resources were discussed, along with various approaches to address them. In laying out these challenges, we aim to inform users about how these issues impact our resources and illustrate ways in which our working together could enhance their accuracy, currency, and overall value.

Alternate JournalProteins
PubMed ID25820941
PubMed Central IDPMC4446195
Grant List077044 / / Wellcome Trust / United Kingdom
099156 / / Wellcome Trust / United Kingdom
G08LM010720 / LM / NLM NIH HHS / United States
P20GM103446 / GM / NIGMS NIH HHS / United States
R01 GM060595 / GM / NIGMS NIH HHS / United States
R01 GM60595 / GM / NIGMS NIH HHS / United States
R01GM080646 / GM / NIGMS NIH HHS / United States
RG/13/5/30112 / / British Heart Foundation / United Kingdom
U41 HG002273 / HG / NHGRI NIH HHS / United States
U41 HG007822 / HG / NHGRI NIH HHS / United States
U41HG007822 / HG / NHGRI NIH HHS / United States
U41HG02273 / HG / NHGRI NIH HHS / United States
Z01 LM000071-13 / / Intramural NIH HHS / United States