TitleAn Interglomerular Circuit Gates Glomerular Output and Implements Gain Control in the Mouse Olfactory Bulb.
Publication TypeJournal Article
Year of Publication2015
AuthorsBanerjee A, Marbach F, Anselmi F, Koh MS, Davis MB, da Silva PGarcia, Delevich K, Oyibo HK, Gupta P, Li B, Albeanu DF
Date Published2015 Jul 1
KeywordsAnimals, Dopamine Plasma Membrane Transport Proteins, Dopaminergic Neurons, GABAergic Neurons, Mice, Neurons, Odors, Olfactory Bulb, Synaptic Transmission

Odors elicit distributed activation of glomeruli in the olfactory bulb (OB). Crosstalk between co-active glomeruli has been proposed to perform a variety of computations, facilitating efficient extraction of sensory information by the cortex. Dopaminergic/GABAergic cells in the OB, which can be identified by their expression of the dopamine transporter (DAT), provide the earliest opportunity for such crosstalk. Here we show in mice that DAT+ cells carry concentration-dependent odor signals and broadcast focal glomerular inputs throughout the OB to cause suppression of mitral/tufted (M/T) cell firing, an effect that is mediated by the external tufted (ET) cells coupled to DAT+ cells via chemical and electrical synapses. We find that DAT+ cells implement gain control and decorrelate odor representations in the M/T cell population. Our results further indicate that ET cells are gatekeepers of glomerular output and prime determinants of M/T responsiveness.

Alternate JournalNeuron
PubMed ID26139373
PubMed Central IDPMC4633092
Grant ListR01 DC012853 / DC / NIDCD NIH HHS / United States
T32 GM065094 / GM / NIGMS NIH HHS / United States