TitleFission yeast spindle dynamics and chromosome segregation fidelity show distinct thermosensitivity.
Publication TypeJournal Article
Year of Publication2024
AuthorsChaba Z, Jain I, Tran PT
JournalMicroPubl Biol
Date Published2024

Cellular processes rely on proteins with temperature-dependent stability and activity. While thermosensitivity in biological networks is well-explored, the effect of temperature on complex mechanochemical assemblies, like the spindle, is rarely studied. We examined fission yeast spindle dynamics and chromosome segregation from 15⁰C to 40⁰C. Our findings reveal that these parameters follow U-shaped temperature-dependent curves but reach their minima at different temperatures. Specifically, spindle dynamics peak around 35⁰C, whereas chromosome segregation defects are minimized at 25⁰C. This suggests a scenario in which mitotic errors are tolerated to expedite rapid cell cycle progression.

Alternate JournalMicroPubl Biol
PubMed ID38287927
PubMed Central IDPMC10823497