Fission yeast spindle dynamics and chromosome segregation fidelity show distinct thermosensitivity.
| Title | Fission yeast spindle dynamics and chromosome segregation fidelity show distinct thermosensitivity. |
| Publication Type | Journal Article |
| Year of Publication | 2024 |
| Authors | Chaba Z, Jain I, Tran PT |
| Journal | MicroPubl Biol |
| Volume | 2024 |
| Date Published | 2024 |
| ISSN | 2578-9430 |
| Abstract | Cellular processes rely on proteins with temperature-dependent stability and activity. While thermosensitivity in biological networks is well-explored, the effect of temperature on complex mechanochemical assemblies, like the spindle, is rarely studied. We examined fission yeast spindle dynamics and chromosome segregation from 15⁰C to 40⁰C. Our findings reveal that these parameters follow U-shaped temperature-dependent curves but reach their minima at different temperatures. Specifically, spindle dynamics peak around 35⁰C, whereas chromosome segregation defects are minimized at 25⁰C. This suggests a scenario in which mitotic errors are tolerated to expedite rapid cell cycle progression. |
| DOI | 10.17912/micropub.biology.001048 |
| Alternate Journal | MicroPubl Biol |
| PubMed ID | 38287927 |
| PubMed Central ID | PMC10823497 |