TitleEcRBPome: a comprehensive database of all known E. coli RNA-binding proteins.
Publication TypeJournal Article
Year of Publication2019
AuthorsGhosh P, Joshi A, Guita N, Offmann B, Sowdhamini R
JournalBMC Genomics
Date Published2019 May 22

The repertoire of RNA-binding proteins (RBPs) in bacteria play a crucial role in their survival, and interactions with the host machinery, but there is little information, record or characterisation in bacterial genomes. As a first step towards this, we have chosen the bacterial model system Escherichia coli, and organised all RBPs in this organism into a comprehensive database named EcRBPome. It contains RBPs recorded from 614 complete E. coli proteomes available in the RefSeq database (as of October 2018). The database provides various features related to the E. coli RBPs, like their domain architectures, PDB structures, GO and EC annotations etc. It provides the assembly, bioproject and biosample details of each strain, as well as cross-strain comparison of occurrences of various RNA-binding domains (RBDs). The percentage of RBPs, the abundance of the various RBDs harboured by each strain have been graphically represented in this database and available alongside other files for user download. To the best of our knowledge, this is the first database of its kind and we hope that it will be of great use to the biological community.

Alternate JournalBMC Genomics
PubMed ID31117939
PubMed Central IDPMC6530084
Grant ListSB/S2/JCB-071/2015 / / JC Bose fellowship, Department of Science and Technology /