TitleA computational view of short-term plasticity and its implications for E-I balance.
Publication TypeJournal Article
Year of Publication2023
AuthorsAsopa A, Bhalla US
JournalCurr Opin Neurobiol
Date Published2023 May 26

Short-term plasticity (STP) and excitatory-inhibitory balance (EI balance) are both ubiquitous building blocks of brain circuits across the animal kingdom. The synapses involved in EI are also subject to short-term plasticity, and several experimental studies have shown that their effects overlap. Recent computational and theoretical work has begun to highlight the functional implications of the intersection of these motifs. The findings are nuanced: while there are general computational themes, such as pattern tuning, normalization, and gating, much of the richness of these interactions comes from region- and modality specific tuning of STP properties. Together these findings point towards the STP-EI balance combination as being a versatile and highly efficient neural building block for a wide range of pattern-specific responses.

Alternate JournalCurr Opin Neurobiol
PubMed ID37245258