AlphaFold opens the doors to deorphanizing secreted proteins.
| Title | AlphaFold opens the doors to deorphanizing secreted proteins. |
| Publication Type | Journal Article |
| Year of Publication | 2024 |
| Authors | Viswanath S |
| Journal | Cell Syst |
| Volume | 15 |
| Issue | 11 |
| Pagination | 1000-1001 |
| Date Published | 2024 Nov 20 |
| ISSN | 2405-4720 |
| Keywords | Computer Simulation, Humans, Ligands, Proteins, Signal Transduction |
| Abstract | Danneskiold-Samsøe and coworkers have developed an in silico screening pipeline based on AlphaFold2 for identifying single-pass transmembrane receptors for secreted peptides that play important roles in cell-cell signaling. Their approach can be used to deorphanize a diverse range of ligands. The overall strategy can be valuable in screening for weak and transient interactions. |
| DOI | 10.1016/j.cels.2024.10.010 |
| Alternate Journal | Cell Syst |
| PubMed ID | 39571530 |