5-HT deletion protects against Clozapine-induced hyperglycemia.
| Title | 5-HT deletion protects against Clozapine-induced hyperglycemia. |
| Publication Type | Journal Article |
| Year of Publication | 2019 |
| Authors | Joshi RSudhir, Singh SPal, Panicker MM |
| Journal | J Pharmacol Sci |
| Volume | 139 |
| Issue | 2 |
| Pagination | 133-135 |
| Date Published | 2018 Dec 18 |
| ISSN | 1347-8648 |
| Abstract | Clozapine is an antipsychotic known for its superior efficacy in treating drug-resistant Schizophrenia. However, Clozapine induces various side effects such as hyperglycemia, agranulocytosis, weight gain etc. The mechanisms of these Clozapine-induced side effects have remained largely elusive though an important role is ascribed to 5-HT (Serotonin receptor subtype-2A). In this pilot study, we report for the first time that the 5-HT 'global' knockout mice (Htr2a) are resistant to the Clozapine-induced hyperglycemia. Importantly though, the Htr2a mice exhibit near normal basal glucose metabolism in the glucose tolerance tests. Collectively, the Htr2a mice provide an important tool to study the Clozapine-induced hyperglycemia. |
| DOI | 10.1016/j.jphs.2018.11.015 |
| Alternate Journal | J. Pharmacol. Sci. |
| PubMed ID | 30600145 |