Title5-HT deletion protects against Clozapine-induced hyperglycemia.
Publication TypeJournal Article
Year of Publication2019
AuthorsJoshi RSudhir, Singh SPal, Panicker MM
JournalJ Pharmacol Sci
Date Published2018 Dec 18

Clozapine is an antipsychotic known for its superior efficacy in treating drug-resistant Schizophrenia. However, Clozapine induces various side effects such as hyperglycemia, agranulocytosis, weight gain etc. The mechanisms of these Clozapine-induced side effects have remained largely elusive though an important role is ascribed to 5-HT (Serotonin receptor subtype-2A). In this pilot study, we report for the first time that the 5-HT 'global' knockout mice (Htr2a) are resistant to the Clozapine-induced hyperglycemia. Importantly though, the Htr2a mice exhibit near normal basal glucose metabolism in the glucose tolerance tests. Collectively, the Htr2a mice provide an important tool to study the Clozapine-induced hyperglycemia.

Alternate JournalJ. Pharmacol. Sci.
PubMed ID30600145