Title5-HT deletion protects against Clozapine-induced hyperglycemia.
Publication TypeJournal Article
Year of Publication2018
AuthorsJoshi RSudhir, Singh SPal, Panicker MM
JournalJ Pharmacol Sci
Date Published2018 Dec 18
ISSN1347-8648
Abstract

Clozapine is an antipsychotic known for its superior efficacy in treating drug-resistant Schizophrenia. However, Clozapine induces various side effects such as hyperglycemia, agranulocytosis, weight gain etc. The mechanisms of these Clozapine-induced side effects have remained largely elusive though an important role is ascribed to 5-HT (Serotonin receptor subtype-2A). In this pilot study, we report for the first time that the 5-HT 'global' knockout mice (Htr2a) are resistant to the Clozapine-induced hyperglycemia. Importantly though, the Htr2a mice exhibit near normal basal glucose metabolism in the glucose tolerance tests. Collectively, the Htr2a mice provide an important tool to study the Clozapine-induced hyperglycemia.

DOI10.1016/j.jphs.2018.11.015
Alternate JournalJ. Pharmacol. Sci.
PubMed ID30600145