NCBS (2007-present)

  1. Surana, P., Vijaya, S. and Nair, D. T.§ RNA-dependent RNA polymerase of Japanese Encephalitis Virus binds the initiator nucleotide GTP to form a mechanistically important pre-initiation state. (2013) Nucleic Acids Research(http://nar.oxfordjournals.org/content/early/2013/11/28/nar.gkt1106.full)
  2. Sharma A., Kottur, J., Narayanan, N. and Nair, D. T.§ A strategically located serine residue is critical for the mutator activity of DNA Polymerase IV from Escherichia coli. Nucleic Acids Research (Featured article on the NAR website-http://www.oxfordjournals.org/our_journals/nar/2013_featured_articles.ht...)
  3. Jain, D. and Nair, D. T.§ (2013) Spacing between core recognition motifs determines relative orientation of AraR monomers on bipartite operators. Nucleic Acids Research 41:639 (http://nar.oxfordjournals.org/content/41/1/639.long)
  4. Sharma, A., Subramanian, V. and Nair, D. T.§ (2012) The PAD region in the mycobacterial dinB homolog MsPolIV exhibits positional heterogeneity. Acta Crystallogr D Biol Crystallogr. 68:960
  5. Sharma, A. and Nair, D. T.§ (2012) MsDpo4—a DinB Homolog from Mycobacterium smegmatis—is an Error-Prone DNA Polymerase that can Promote G:T and T:G Mismatches. Journal of Nucleic Acids, vol. 2012, Article ID 285481. (http://www.hindawi.com/journals/jna/2012/285481/)
  6. Sharma A. and Nair, D. T.§ (2011) Cloning, expression, purification, crystallization and preliminary crystallographic analysis of MsDpo4: a Y-family DNA polymerase from Mycobacterium smegmatis. Acta Crystallogr Sect F Struct Biol Cryst Commun. 67:812.
  7. Nair, D. T., Johnson, R. E., Prakash, L., Prakash, S. and Aggarwal, A. K. (2011) DNA Synthesis across an Abasic Lesion by Yeast Rev1 DNA Polymerase. J Mol Biol. 406:18.
  8. Namadurai, S.*, Jain, D.*, Kulkarni, D. S.*, Tabib, C. R., Friedhoff, P., Rao, D. N. and Nair, D. T.§ (2010) The C-terminal domain of the MutL homolog from Neisseria gonorrhoeae forms an inverted homodimer. PLoS One. 5:e13726. (http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0013726)
  9. Jain, R., Nair, D.T., Johnson, R. E., Prakash, S., Prakash, L. and Aggarwal, A. K. (2009) Replication across template T/U by human DNA polymerase-iota. Structure. 17:974.
  10. Nair, D.T., Johnson, R. E., Prakash, S., Prakash, L. and Aggarwal, A. K. (2009) DNA synthesis across an abasic lesion by human DNA polymerase iota. Structure. 17:530.
  11. Gupta, Y.K., Nair, D.T., Wharton, R. P., and Aggarwal, A. K. (2008). Structures of Human Pumilio with Noncognate RNAs Reveal Molecular Mechanisms for Binding Promiscuity. Structure. 16:549.
  12. Nair, D.T.*, Johnson, R. E.*, Prakash, S., Prakash, L. and Aggarwal, A. K. (2008) Protein-template directed synthesis across an acrolein-derived DNA adduct by yeast Rev1 DNA Polymerase. Structure. 16:239.

(§= corresponding author; *Equal contribution)

Structures Deposited in the PDB from NCBS: 3NCV, 4DEZ, 4EGY, 4EGZ, 4H0E, 4IRC, 4IR9, 4IR1, 4IRD and 4IRK.

Mount Sinai Medical Centre (2002-2007)

  1. Lone, S.*, Townson, S. A.*, Uljon, S. N.*, Johnson, R. E., Brahma, A., Nair, D.T., Prakash, S., Prakash, L. and Aggarwal, A. K. (2007) Human DNA Polymerase kappa encircles DNA: implications for mismatch extension and lesion bypass.Mol. Cell. 25:601
  2. Nair, D.T.*, Johnson, R. E.*, Prakash, S., Prakash, L. and Aggarwal, A. K. (2006) Hoogsteen base pair formation promotes synthesis opposite the 1,N6-ethenodeoxyadenosine lesion by human DNA Polymerase iota. Nat. Struct. Mol. Biol. 13:619
  3. Nair, D.T., Johnson, R. E., Prakash, S., Prakash, L. and Aggarwal, A. K. (2006)  Incoming nucleotide imposes a syn conformation on templating purine in the human DNA polymerase iota active site. Structure (Camb). 14:749
  4. Nair, D.T., Johnson, R. E., Prakash, S., Prakash, L. and Aggarwal, A. K. (2005) Human DNA Polymerase iota incorporates dCTP opposite template G via a G.C+ Hoogsteen base pair. Structure (Camb). 13:1569
  5. Nair, D.T., Johnson, R. E., Prakash, S., Prakash, L. and Aggarwal, A. K. (2005) Rev1 employs a novel mechanism of DNA synthesis using a protein template. Science. 309:2219
  6. Nair, D.T., Johnson, R. E., Prakash, S., Prakash, L. and Aggarwal, A. K. (2004) Replication by human DNA polymerase-iota occurs by Hoogsteen base-   pairing. Nature. 430:377.

(*Equal contribution)

National Institute of Immunology (1996-2001)

  1. Nair, D.T., Kaur, K. J., Singh, K., Mukherjee, P., Rajagopal, D., George, A., Bal, V., Rath, S., Rao, K. V. and Salunke, D. M. (2003) Mimicry of native peptide antigens by the corresponding retro-inverso analogs is dependent on their intrinsic structure and interaction propensities. J. Immunol. 170:1362
  2. Nair, D.T., Singh, K., Siddiqui, Z., Nayak, B. P., Rao, K. V. S. and Salunke, D. M. (2002) Epitope recognition by diverse antibodies suggests conformational convergence in an antibody response. J. Immunol. 168:2371
  3. Nayak, S.K., Bagga, S., Gaur, D., Nair, D.T., Salunke, D.M. and Batra, J.K. Mechanism of specific target recognition and RNA hydrolysis by ribonucleolytictoxin restrictocin. (2001) Biochemistry. 40:9115
  4. *Jain, D., *Nair, D.T., Swaminathan, G. J., Abraham, E.G., Nagaraju, J. and Salunke, D.M. (2001) Structure of the Induced Antibacterial Protein from Tasar Silkworm, Antherea mylitta: Implications to molecular evolution. (2001) J. Biol. Chem. 276:41377
  5. Nair, D.T., Singh, K., Shahu, N., Rao, K. V. S. and Salunke, D. M. (2000). Crystal structure of an antibody bound to an immunodominant peptide epitope: novel features in peptide-antibody recognition. J. Immunol. 165:6949

(*Equal contribution)

  Fellowships, Awards and Honors

1. Ramanujan Fellowship (2008-2013): Deepak T. Nair

2. Innovative Young Biotechnology Award (2012-2015): Deepti Jain

3. CSIR Student Fellowship: Amit Sharma, Shivlee Nirwal, Jithesh Kottur, Manhar Singh Rawat

4. UGC Student Fellowship: Rahul Sharma

5. ICMR Student Fellowship: Naveen Narayanan

6. Best Poster Award at the NCBS Annual Talks (2012): Dr. Deepti Jain 

7. Prof. K. Venkatesan Award at the 42nd National Seminar on Crystallography  (2013): Shivlee Nirwal

8. Award for Best Oral Presentation at the 42nd National Seminar on Crystallography(2013): Parag Surana