Organ Mechanicanobiology Lab

We are interested in understanding the role of physical forces and their interaction with biochemical signals in regulating robust organ morphogenesis and homeostasis. By elucidating the biomechanical principles guiding organogensis, we aim to provide insights into the mechanisms underlying congenital disorders and tumorigenesis.

Our research uses the C. elegans reproductive system (gonad) as a model for studying organogenesis. We employ interdisciplinary approaches, including tissue-specific genetic manipulations, CRISPR-based knock-in/out techniques, quantitative live imaging, and biophysical methods such as laser ablations, optogenetics, and microfluidics for high-throughput, long-term imaging. Additionally, we integrate -omics approaches and theoretical modeling in collaboration with others to gain a comprehensive understanding of organ development.

For more details, please go to the " Research page"