Genes and Genomes
Genes and Genomes
The bacterial world
The discovery and place of bacteria in tree of life – from early approaches to molecular methods, molecular chronometers, protein-coding genes, how protein-coding genes change, hierarchies in protein sequence organisation
Quantifying gene sequence change
Sequence alignments and their meaning, from alignments and simple models of sequence evolution to evolutionary distances, building phylogenies
Genome organisation
Gene content in bacterial and eukaryotic genomes, c-value paradox, the cost of gene, minimal gene complements for cellular life
Genome evolution
Genome growth and shrinkage, horizontal gene transfer and duplication, costs and benefits of gene acquisition
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Course Outcomes |
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After completing this course, the student will be able to: |
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CO1 |
Understand the structure and organisation of bacterial genes, and how they change over time |
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CO2 |
Understand how genes and other elements are put together to create genomes in bacteria and higher eukaryotes |
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CO3 |
Understand the different ways in which minimal gene complements are put together in bacteria |
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CO4 |
Understand the processes that drive genome expansion and contraction in bacteria, with some basic comparisons with equivalents in eukaryotes |