Histone variants: Distinct building blocks of the chromatin acting at the core.
| Title | Histone variants: Distinct building blocks of the chromatin acting at the core. |
| Publication Type | Journal Article |
| Year of Publication | 2025 |
| Authors | Gandhivel VHari-Sunda, Shivaprasad PV |
| Journal | Curr Opin Plant Biol |
| Volume | 89 |
| Pagination | 102829 |
| Date Published | 2025 Dec 04 |
| ISSN | 1879-0356 |
| Abstract | Histone variants alter the core properties of the nucleosomes they decorate and hence constitute a significant epigenetic layer to control cellular processes. Historically, histone variants have been studied using classical genetics to implicate the functions associated with them. However, over the last few years, advanced (epi)genomics and structural investigations have revealed the fine molecular steps involved in histone variant-specific genome regulation. This review outlines the key mechanistic findings that uncovered both structural and functional aspects of plant histone variants in unprecedented resolution. We also highlight the key avenues that might hold potential for future studies, including chromatin engineering using histone variants. |
| DOI | 10.1016/j.pbi.2025.102829 |
| Alternate Journal | Curr Opin Plant Biol |
| PubMed ID | 41349210 |