Generation of feeder-independent transgene-free iPSC lines from a young-onset Parkinson's disease (YOPD) patient with a homozygous PLA2G6: c.2222G>A (p. Arg741Gln) mutation (NCBSi003-A) and unaffected heterozygous parent (NCBSi004-A).
| Title | Generation of feeder-independent transgene-free iPSC lines from a young-onset Parkinson's disease (YOPD) patient with a homozygous PLA2G6: c.2222G>A (p. Arg741Gln) mutation (NCBSi003-A) and unaffected heterozygous parent (NCBSi004-A). |
| Publication Type | Journal Article |
| Year of Publication | 2023 |
| Authors | Gopurappilly R, Musthafa T, Sukumaran S, Viswanath B, Hasan G |
| Journal | Stem Cell Res |
| Volume | 67 |
| Pagination | 103033 |
| Date Published | 2023 Jan 24 |
| ISSN | 1876-7753 |
| Abstract | Phospholipase A2 group 6 (PLA2G6, iPLA2β or PARK14) gene encodes a calcium-independent group 6 phospholipase A2 enzyme and is associated with young-onset autosomal recessive Parkinson's disease (PD). We generated human induced pluripotent stem cell (iPSC) lines from a patient with young-onset PD carrying a homozygous PLA2G6: c.2222G>A (p. Arg741Gln) mutation (NCBSi003-A) and unaffected heterozygous parent (NCBSi004-A). These iPSC lines will be used for investigating the key molecular signatures of young-onset PD (YOPD), and to understand the predictive phenotypes of the disease. |
| DOI | 10.1016/j.scr.2023.103033 |
| Alternate Journal | Stem Cell Res |
| PubMed ID | 36706537 |