TitleDesigning DNA nanodevices for compatibility with the immune system of higher organisms.
Publication TypeJournal Article
Year of Publication2015
AuthorsSurana S, Shenoy AR, Krishnan Y
JournalNat Nanotechnol
Date Published2015 Sep

DNA is proving to be a powerful scaffold to construct molecularly precise designer DNA devices. Recent trends reveal their ever-increasing deployment within living systems as delivery devices that not only probe but also program and re-program a cell, or even whole organisms. Given that DNA is highly immunogenic, we outline the molecular, cellular and organismal response pathways that designer nucleic acid nanodevices are likely to elicit in living systems. We address safety issues applicable when such designer DNA nanodevices interact with the immune system. In light of this, we discuss possible molecular programming strategies that could be integrated with such designer nucleic acid scaffolds to either evade or stimulate the host response with a view to optimizing and widening their applications in higher organisms.

Alternate JournalNat Nanotechnol
PubMed ID26329110
Grant List500095/Z/09/Z / / Wellcome Trust / United Kingdom