Design of ultrasensitive DNA-based fluorescent pH sensitive nanodevices.
|Title||Design of ultrasensitive DNA-based fluorescent pH sensitive nanodevices.|
|Publication Type||Journal Article|
|Year of Publication||2015|
|Authors||Halder S, Krishnan Y|
|Date Published||2015 Jun 14|
Here we tune the pH sensitivity of a DNA-based conformational switch, called the I-switch, to yield a set of fluorescent pH sensitive nanodevices with a collective, expanded pH sensing regime from 5.3 to 7.5. The expanded pH regime of this new family of I-switches originates from a dramatic improvement in the overall percentage signal change in response to pH of these nanodevices.
|Grant List||/ / Wellcome Trust / United Kingdom|