TitleDesign of ultrasensitive DNA-based fluorescent pH sensitive nanodevices.
Publication TypeJournal Article
Year of Publication2015
AuthorsHalder S, Krishnan Y
JournalNanoscale
Volume7
Issue22
Pagination10008-12
Date Published2015 Jun 14
ISSN2040-3372
Abstract

Here we tune the pH sensitivity of a DNA-based conformational switch, called the I-switch, to yield a set of fluorescent pH sensitive nanodevices with a collective, expanded pH sensing regime from 5.3 to 7.5. The expanded pH regime of this new family of I-switches originates from a dramatic improvement in the overall percentage signal change in response to pH of these nanodevices.

DOI10.1039/c5nr01158b
Alternate JournalNanoscale
PubMed ID25990365
Grant List / / Wellcome Trust / United Kingdom