Derivation of iPSC lines from two patients with familial Alzheimer's disease from India.
|Title||Derivation of iPSC lines from two patients with familial Alzheimer's disease from India.|
|Publication Type||Journal Article|
|Year of Publication||2018|
|Authors||Najar AH, Sneha KM, Ashok A, Babu S, Subramaniam AG, Kannan R, Viswanath B, Purushottam M, Varghese M, Parvez S, Panicker MM, Mukherjee O, Jain S|
|Journal||Stem Cell Res|
|Date Published||2018 Dec 19|
The current prevalence of diagnosable dementia in India is 1% of people over 60 years (~3.7 million people), but is estimated to increase significantly, as ~15% world's aged population (>65 years) would be resident here by 2020 (Shah et al., 2016). While several mutations that pose a familial risk have been identified, the ethnic background may influence disease susceptibility, clinical presentation and treatment response. In this study, we report a detailed characterization of two representative HiPSC lines from a well-characterized dementia cohort from India. Availability of these lines, and associated molecular and clinical information, would be useful in the detailed exploration of the genomic contribution(s) to AD.
|Alternate Journal||Stem Cell Res|