TitleDerivation of iPSC lines from two patients with familial Alzheimer's disease from India.
Publication TypeJournal Article
Year of Publication2018
AuthorsNajar AH, Sneha KM, Ashok A, Babu S, Subramaniam AG, Kannan R, Viswanath B, Purushottam M, Varghese M, Parvez S, Panicker MM, Mukherjee O, Jain S
JournalStem Cell Res
Volume34
Pagination101370
Date Published2018 Dec 19
ISSN1876-7753
Abstract

The current prevalence of diagnosable dementia in India is 1% of people over 60 years (~3.7 million people), but is estimated to increase significantly, as ~15% world's aged population (>65 years) would be resident here by 2020 (Shah et al., 2016). While several mutations that pose a familial risk have been identified, the ethnic background may influence disease susceptibility, clinical presentation and treatment response. In this study, we report a detailed characterization of two representative HiPSC lines from a well-characterized dementia cohort from India. Availability of these lines, and associated molecular and clinical information, would be useful in the detailed exploration of the genomic contribution(s) to AD.

DOI10.1016/j.scr.2018.101370
Alternate JournalStem Cell Res
PubMed ID30605839