Beyond the coding genome: non-coding mutations and cancer.
|Title||Beyond the coding genome: non-coding mutations and cancer.|
|Publication Type||Journal Article|
|Year of Publication||2020|
|Authors||Walavalkar K, Notani D|
|Journal||Front Biosci (Landmark Ed)|
|Date Published||2020 Jun 01|
Latest advancements in genomics involving individuals from different races and geographical locations has led to the identification of thousands of common as well as rare genetic variants and copy number variations (CNVs). These studies have surprisingly revealed that the majority of genetic variation is not present within the coding region but rather in the non-coding region of the genome, which is also termed as "Medical Genome". This short review describes how mutations/variations within; regulatory sequences, architectural proteins and transcriptional regulators give rise to the aberrant gene expression profiles that drives cellular transformations and malignancies.
|Alternate Journal||Front Biosci (Landmark Ed)|