Admissions - inStem Projects
inStem Projects
The following projects are available for students with fellowships. Please contact the respective faculty members for further details.
Highly exploratory projects are available in four areas: (1) systems-level organizational frameworks of metabolic networks, (2) metabolic oscillations and rhythms, coupled to key metabolic sensors, (3) the evolution of metabolic pathways, and (4) resource exchange between cells.
Requirements:
Students must have fellowships/
Students must have either strong backgrounds/interests in systems-level studies (and can write code), and/or strong foundations in analytical chemistry & biochemistry. More about these diverse areas of our research can be found at https://sunillaxmanlab.weebly.com/ ).
Contact: sunil at instem.res.in
Human in vitro disease modelling of mental illness- “Disease in a dish” model of human cerebral cortex development
Our lab studies the cellular and molecular mechanisms of neurodevelopmental disorders like schizophrenia (SZ) and bipolar disorder(BPD).
In this project we would like to study the potentially damaging effect of deleterious genetic risk variants in epigenetic modifiers and identify altered neurobiological pathways. We will generate 3D cerebral organoid cultures from patient iPSCs to model human brain development in a dish. These cerebral organoids will be used to study altered cellular neural development phenotypes, which lead to clinical symptoms of the disease.
Thus, this project will provide valuable insights into understanding how pathological mutations disturb the normal process of chromatin regulation during cortical development leading to neurodevelopmental disorder.
Contact: bhavanam at instem.res.in
Research projects in the area of tissue health and disease are available. Our focus in these domains are on understanding the mechanisms underlying the remarkable capacity of the skin for regeneration and repair and the pathologies that arise when these systems are perturbed. The projects cover the spectrum from basic biology to translational research in collaboration with industry partners. Further information can be found at https://www.instem.res.in/faculty/colin and https://jamoralab.weebly.com
Applicant interested in pursuing this opportunity can discuss them further with Colin Jamora (colinj@instem.res.in)