
@article {134601,
	title = {Clustering of lipids driven by integrin.},
	journal = {Soft Matter},
	volume = {19},
	year = {2023},
	month = {2023 Sep 13},
	pages = {6814-6824},
	abstract = {<p>Integrin is an important transmembrane receptor protein which remodels the actin network and anchors the cell membrane towards the extracellular matrix mechanochemical pathways. The clustering of specific lipids and lipid-anchored proteins, which is essential for a certain type of endocytosis process, is facilitated at integrin-mediated active regions. To study this, we propose a minimal exactly solvable model which includes the interplay of stochastic shuttling between integrin on and off states with the intrinsic dynamics of the membrane. We propose a two-step mechanism in which the integrin induces an aster-like arrangement in the actin network, followed by clustering of lipids in that region. We obtain an analytic expression for the deformation and local membrane velocity, and thereby the evolution of clustering mediated by a single integrin. The deformation evolves nonmonotonically and its dependence on the stochastic shuttling timescales and membrane properties is elucidated. Our estimates of the area of the deformed region and the number of lipids in it indicate strong clustering.</p>
},
	keywords = {Actins, Cell Membrane, Cluster Analysis, Integrins, Lipids, Membrane Proteins},
	issn = {1744-6848},
	doi = {10.1039/d3sm00809f},
	author = {Singha, Tapas and Polley, Anirban and Barma, Mustansir}
}
@article {11587,
	title = {Nonequilibrium description of de novo biogenesis and transport through Golgi-like cisternae.},
	journal = {Sci Rep},
	volume = {6},
	year = {2016},
	month = {2016 Dec 19},
	pages = {38840},
	abstract = {<p>A central issue in cell biology is the physico-chemical basis of organelle biogenesis in intracellular trafficking pathways, its most impressive manifestation being the biogenesis of Golgi cisternae. At a basic level, such morphologically and chemically distinct compartments should arise from an interplay between the molecular transport and chemical maturation. Here, we formulate analytically tractable, minimalist models, that incorporate this interplay between transport and chemical progression in physical space, and explore the conditions for de novo biogenesis of distinct cisternae. We propose new quantitative measures that can discriminate between the various models of transport in a qualitative manner-this includes measures of the dynamics in steady state and the dynamical response to perturbations of the kind amenable to live-cell imaging.</p>
},
	issn = {2045-2322},
	doi = {10.1038/srep38840},
	author = {Sachdeva, Himani and Barma, Mustansir and Rao, Madan}
}
