@article {164008, title = {GRAYU: graph-based database integrating Ayurvedic formulations, medicinal plants, phytochemicals and diseases}, journal = {frontiers}, volume = {16}, year = {2026}, month = {22 January 2026}, abstract = {

The translation of India{\textquoteright}s extensive traditional knowledge on indigenous medicinal plants into modern therapeutic solutions is contingent upon a systematic framework. While traditional Indian medicine offers a rich source of therapeutic leads, this knowledge is often not structured for modern computational analysis, creating a barrier to systematic drug discovery.
To this end, we present GRAYU, a curated and comprehensive online database that integrates data across multiple categories, connecting 1,039 traditional formulations to 12,743 indigenous plants, 129,542 phytochemicals, and 13,480 indicated diseases.\ 
GRAYU provides insights into 1,370,257 plant-phytochemical, 116,531 plant-disease, 2,389 plant-formulation, and 4,087 formulation-disease associations. We show potential applications on phytochemical analogs, sustainable plant substitution, and disease-network analysis, highlighting the potential of integrative graphs to decode shared molecular signatures and therapeutic networks across traditional Ayurvedic formulations.
GRAYU represents a user-friendly resource for researchers to investigate complex bio-associations and formulate novel therapeutic hypotheses, with insights from traditional Indian medicine. GRAYU organises reported associations and computational relationships and can hint at mechanistic causality or biological activity; however, all outputs require contextual interpretation and further experimental validation.

}, keywords = {Data integration, Drug repurposing, Endangered plants, Knowledge graph, Network pharmacology, Traditional foods}, doi = {https://doi.org/10.3389/fphar.2025.1727224}, author = {Sarthak Joshi and Aditi Pathak and Dheemanth Reddy Regati and Revathy Menon and Deepthi S. Ajith and Aditya Sheshadri and Neerja Viswanathan and Poulomi Ray and Vimarishi Koul and Pratishruti Panda and Shriya Anand Bhambore and Shailya Verma and Ananya Sinha and K. Mohamed Shafi and Murugavel Pavalam and Ramanathan Sowdhamini} }