
@article {165836,
	title = {A growing role for ER-Ca2+ release and store-operated Ca2+ entry in neuronal physiology and pathophysiology},
	journal = {Current Opinion in Neurobiology},
	volume = {98},
	year = {2026},
	pages = {103195},
	abstract = {<p>Among its many functions, the endoplasmic reticulum (ER) in eukaryotes serves as a store for intracellular Ca2+. In metazoan cells, there are two classes of ER membrane localized channels that release intracellular Ca2+ in response to external signals. ER-Ca2+ release is followed by extracellular Ca2+ entry through a process called store-operated Ca2+ entry (SOCE), essential for cellular Ca2+ signaling and homeostasis. Recent findings suggest that neuronal SOCE differs based on the nature of ER-Ca2+ release channels activated and the architecture of the ER across neuronal compartments. These properties determine the amplitude and time of ER-Ca2+ release and SOCE, which in turn determine activation of downstream effector molecules. The importance of these findings is discussed in the context of normal physiology and neurodegenerative conditions. Drugs targeting regulators of ER-Ca2+ release and SOCE show promise in terms of reverting symptoms of neurodegenerative conditions such as Alzheimers{\textquoteright} disease.</p>
},
	issn = {0959-4388},
	doi = {https://doi.org/10.1016/j.conb.2026.103195},
	url = {https://www.sciencedirect.com/science/article/pii/S0959438826000310},
	author = {Gaiti Hasan}
}
@article {156923,
	title = {Lysosomal TPC2 channels disrupt Ca2+ entry and dopaminergic function in models of LRRK2-Parkinson{\textquoteright}s disease},
	year = {2025},
	doi = {10.1083/jcb.202412055},
	url = {https://doi.org/10.1083/jcb.202412055},
	author = {Martina Gregori and Gustavo J.S. Pereira and Robert Allen and Nicholas West and Kai-Yin Chau and Xinjiang Cai and Matthew P. Bostock and Stephen R. Bolsover and Marco Keller and Chiao-Yin Lee and Si Hang Lei and Kirsten Harvey and Franz Bracher and Christian Grimm and Gaiti Hasan and Matthew E. Gegg and Anthony H.V. and Sean T. Sweeney and Sandip Patel}
}
