
@article {154353,
	title = {Growth factor-triggered de-sialylation controls glycolipid-lectin-driven endocytosis.},
	journal = {Nat Cell Biol},
	year = {2025},
	month = {2025 Feb 21},
	abstract = {<p>Glycolipid-lectin-driven endocytosis controls the formation of clathrin-independent carriers and the internalization of various cargos such as β1 integrin. Whether this process is regulated in a dynamic manner remained unexplored. Here we demonstrate that, within minutes, the epidermal growth factor triggers the galectin-driven endocytosis of cell-surface glycoproteins, such as integrins, that are key regulators of cell adhesion and migration. The onset of this process-mediated by the Na/H antiporter NHE1 as well as the neuraminidases Neu1 and Neu3-requires the pH-triggered enzymatic removal of sialic acids whose presence otherwise prevents galectin binding. De-sialylated glycoproteins are then retrogradely transported to the Golgi apparatus where their glycan make-up is reset to regulate EGF-dependent invasive-cell migration. Further evidence is provided for a role of neuraminidases and galectin-3 in acidification-dependent bone resorption. Glycosylation at the cell surface thereby emerges as a dynamic and reversible regulatory post-translational modification that controls a highly adaptable trafficking pathway.</p>
},
	issn = {1476-4679},
	doi = {10.1038/s41556-025-01616-x},
	url = {https://pubmed.ncbi.nlm.nih.gov/39984654/},
	author = {MacDonald, Ewan and Forrester, Alison and Valades-Cruz, Cesar A and Madsen, Thomas D and Hetmanski, Joseph H R and Dransart, Estelle and Ng, Yeap and Godbole, Rashmi and Shp, Ananthan Akhil and Leconte, Ludovic and Chambon, Val{\'e}rie and Ghosh, Debarpan and Pinet, Alexis and Bhatia, Dhiraj and Lombard, B{\'e}rang{\`e}re and Loew, Damarys and Larsen, Martin R and Leffler, Hakon and Lefeber, Dirk J and Clausen, Henrik and Blangy, Anne and Caswell, Patrick and Shafaq-Zadah, Massiullah and Mayor, Satyajit and Weigert, Roberto and Wunder, Christian and Johannes, Ludger}
}
