
@article {157493,
	title = {Artery regeneration: Molecules, mechanisms and impact on organ function.},
	journal = {Semin Cell Dev Biol},
	volume = {171},
	year = {2025},
	month = {2025 May 02},
	pages = {103611},
	abstract = {<p>Replenishment of artery cells to repair or create new arteries is a promising strategy to re-vascularize ischemic tissue. However, limited understanding of cellular and molecular programs associated with artery (re-)growth impedes our efforts towards designing optimal therapeutic approaches. In this review, we summarize different cellular mechanisms that drive injury-induced artery regeneration in distinct organs and organisms. Artery formation during embryogenesis includes migration, self-amplification, and changes in cell fates. These processes are coordinated by multiple signaling pathways, like Vegf, Wnt, Notch, Cxcr4; many of which, also involved in injury-induced vascular responses. We also highlight how physiological and environmental factors determine the extent of arterial re-vascularization. Finally, we discuss different in vitro cellular reprogramming and tissue engineering approaches to promote artery regeneration, in vivo. This review provides the current understanding of endothelial cell fate reprogramming and explores avenues for regenerating arteries to restore organ function through efficient revascularization.</p>
},
	keywords = {Artery; Cellular reprogramming; Collateral arteries; Development; Endothelial cells; Genetic lineage tracing; Regeneration.},
	issn = {1096-3634},
	doi = {10.1016/j.semcdb.2025.103611},
	url = {https://www.sciencedirect.com/science/article/pii/S1084952125000217?via\%3Dihub},
	author = {Ghosh, Swarnadip and Bishnoi, Bhavnesh and Das, Soumyashree}
}
@article {149384,
	title = {Development of pial collaterals by extension of pre-existing artery tips.},
	journal = {Cell Rep},
	volume = {43},
	year = {2024},
	month = {2024 Sep 24},
	pages = {114771},
	abstract = {<p>Pial collaterals provide protection from ischemic damage and improve the prognosis of stroke patients. The origin or precise sequence of events underlying pial collateral development is unclear and has prevented clinicians from adapting new vascularization and regeneration therapies. We use genetic lineage tracing and intravital imaging of mouse brains at cellular resolution to show that during embryogenesis, pial collateral arteries develop from extension and anastomoses of pre-existing artery tips in a VegfR2-dependent manner. This process of artery tip extension occurs on pre-determined microvascular tracks. Our data demonstrate that an arterial receptor, Cxcr4, earlier shown to drive artery cell migration and coronary collateral development, is dispensable for the formation and maintenance of pial collateral arteries. Our study shows that collateral arteries of the brain are built by a mechanism distinct from that of the heart.</p>
},
	issn = {2211-1247},
	doi = {10.1016/j.celrep.2024.114771},
	author = {Kumar, Suraj and Ghosh, Swarnadip and Shanavas, Niloufer and Sivaramakrishnan, Vinayak and Dwari, Manish and Das, Soumyashree}
}
