
@article {3571,
	title = {Glial and neuronal Semaphorin signaling instruct the development of a functional myotopic map for Drosophila walking.},
	journal = {Elife},
	volume = {5},
	year = {2016},
	month = {2016},
	abstract = {<p>Motoneurons developmentally acquire appropriate cellular architectures that ensure connections with postsynaptic muscles and presynaptic neurons. In Drosophila, leg motoneurons are organized as a myotopic map, where their dendritic domains represent the muscle field. Here, we investigate mechanisms underlying development of aspects of this myotopic map, required for walking. A behavioral screen identified roles for Semaphorins (Sema) and Plexins (Plex) in walking behavior. Deciphering this phenotype, we show that PlexA/Sema1a mediates motoneuron axon branching in ways that differ in the proximal femur and distal tibia, based on motoneuronal birth order. Importantly, we show a novel role for glia in positioning dendrites of specific motoneurons; PlexB/Sema2a is required for dendritic positioning of late-born motoneurons but not early-born motoneurons. These findings indicate that communication within motoneurons and between glia and motoneurons, mediated by the combined action of different Plexin/Semaphorin signaling systems, are required for the formation of a functional myotopic map.</p>
},
	issn = {2050-084X},
	doi = {10.7554/eLife.11572},
	author = {Syed, Durafshan Sakeena and Gowda, Swetha B M and Reddy, O Venkateswara and Reichert, Heinrich and VijayRaghavan, K}
}
