
@article {118405,
	title = {Development of a Systematic Strategy toward Promotion of α-Synuclein Aggregation Using 2-Hydroxyisophthalamide-Based Systems. },
	journal = {Biochemistry},
	year = {2022},
	month = {10/2022},
	abstract = {<p>Establishing a potent scheme against α-synuclein aggregation involved in Parkinson{\textquoteright}s disease has been evaluated as a promising route to identify compounds that either inhibit or promote the aggregation process of α-synuclein. In the last two decades, this perspective has guided a dramatic increase in the efforts, focused on developing potent drugs either for retardation or promotion of the self-assembly process of α-synuclein. To address this issue, using a chemical kinetics platform, we developed a strategy that enabled a progressively detailed analysis of the molecular events leading to protein aggregation at the microscopic level in the presence of a recently synthesized 2-hydroxyisophthalamide class of small organic molecules based on their binding affinity. Furthermore, qualitatively, we have developed a strategy of disintegration of α-synuclein fibrils in the presence of these organic molecules. Finally, we have shown that these organic molecules effectively suppress the toxicity of α-synuclein oligomers in neuron cells.</p>
},
	doi = {10.1021/acs.biochem.2c00371},
	author = {Uddin, A and Malla, J A and Kumar, H and Kumari, M and Sinha, S and Sharma, VK and Kumar, Y and Talukdar, P and Lahiri, M and Maiti, TK and Hazra, P}
}
