
@article {1037,
	title = {An Interglomerular Circuit Gates Glomerular Output and Implements Gain Control in the Mouse Olfactory Bulb.},
	journal = {Neuron},
	volume = {87},
	year = {2015},
	month = {2015 Jul 1},
	pages = {193-207},
	abstract = {<p>Odors elicit distributed activation of glomeruli in the olfactory bulb (OB). Crosstalk between co-active glomeruli has been proposed to perform a variety of computations, facilitating efficient extraction of sensory information by the cortex. Dopaminergic/GABAergic cells in the OB, which can be identified by their expression of the dopamine transporter (DAT), provide the earliest opportunity for such crosstalk. Here we show in mice that DAT+ cells carry concentration-dependent odor signals and broadcast focal glomerular inputs throughout the OB to cause suppression of mitral/tufted (M/T) cell firing, an effect that is mediated by the external tufted (ET) cells coupled to DAT+ cells via chemical and electrical synapses. We find that DAT+ cells implement gain control and decorrelate odor representations in the M/T cell population. Our results further indicate that ET cells are gatekeepers of glomerular output and prime determinants of M/T responsiveness.</p>
},
	keywords = {Animals, Dopamine Plasma Membrane Transport Proteins, Dopaminergic Neurons, GABAergic Neurons, Mice, Neurons, Odors, Olfactory Bulb, Synaptic Transmission},
	issn = {1097-4199},
	doi = {10.1016/j.neuron.2015.06.019},
	author = {Banerjee, Arkarup and Marbach, Fred and Anselmi, Francesca and Koh, Matthew S and Davis, Martin B and Garcia da Silva, Pedro and Delevich, Kristen and Oyibo, Hassana K and Gupta, Priyanka and Li, Bo and Albeanu, Dinu F}
}
@article {857,
	title = {Olfactory bulb coding of odors, mixtures and sniffs is a linear sum of odor time profiles.},
	journal = {Nat Neurosci},
	volume = {18},
	year = {2015},
	month = {2015 Feb},
	pages = {272-81},
	abstract = {<p>The olfactory system receives intermittent and fluctuating inputs arising from dispersion of odor plumes and active sampling by the animal. Previous work has suggested that the olfactory transduction machinery and excitatory-inhibitory olfactory bulb circuitry generate nonlinear population trajectories of neuronal activity that differ across odorants. Here we show that individual mitral/tufted (M/T) cells sum inputs linearly across odors and time. By decoupling odor sampling from respiration in anesthetized rats, we show that M/T cell responses to arbitrary odor waveforms and mixtures are well described by odor-specific impulse responses convolved with the odorant{\textquoteright}s temporal profile. The same impulse responses convolved with the respiratory airflow predict the classical respiration-locked firing of olfactory bulb neurons and several other reported response properties of M/T cells. These results show that the olfactory bulb linearly processes fluctuating odor inputs, thereby simplifying downstream decoding of stimulus identity and temporal dynamics.</p>
},
	keywords = {Animals, Female, Models, Neurological, Neurons, Odors, Olfactory Bulb, Olfactory Perception, Olfactory Receptor Neurons, Rats, Rats, Wistar, Respiration, Time Factors},
	issn = {1546-1726},
	doi = {10.1038/nn.3913},
	author = {Gupta, Priyanka and Albeanu, Dinu F and Bhalla, Upinder S}
}
