
@article {95781,
	title = {RNA diversification by a self-reproducing ribozyme revealed by deep sequencing and kinetic modelling.},
	journal = {Chem Commun (Camb)},
	year = {2021},
	month = {2021 Jul 08},
	abstract = {<p>We demonstrate that a recombinase ribozyme achieves multiple functions in the same reaction network: self-reproduction, iterative elongation and circularization of other RNAs, leading to synthesis of diverse products predicted by a kinetic model. This shows that key mechanisms can be integrated and controlled toward Darwinian evolution in RNA reaction networks.</p>
},
	issn = {1364-548X},
	doi = {10.1039/d1cc02290c},
	author = {Jeancolas, Cyrille and Matsubara, Yoshiya J and Vybornyi, Mykhailo and Lambert, Camille N and Blokhuis, Alex and Alline, Thomas and Griffiths, Andrew D and Ameta, Sandeep and Krishna, Sandeep and Nghe, Philippe}
}
