
@article {152142,
	title = {Non-coding genetic variants underlying higher prostate cancer risk in men of African ancestry.},
	journal = {Res Sq},
	year = {2024},
	month = {2024 Dec 05},
	abstract = {<p>Incidence and severity of prostate cancer (PrCa) substantially varies across ancestries. American men of African ancestry (AA) are more likely to be diagnosed with and die from PrCa than the those of European ancestry (EA). Published polygenic risk scores for developing prostate cancer, even those based on multi-ancestry genome-wide association studies, do not address population-specific genetic mechanisms underlying PrCa risk in men of African ancestry. Specifically, the role of non-coding regulatory polymorphisms in driving inter-ancestry variation in PrCa has not been suficiently explored. Here, by employing a sequence-based deep learning model of prostate regulatory enhancers, we identified ~ 2,000 SNPs with higher alternate allele frequency in AA men that potentially affect enhancer function associated with PrCa susceptibility, as supported by our experimental validation. The identified enhancer SNPs (eSNPs) may influence PrCa development through two complementary mechanisms: 1) the alternate allele that increase enhancer activity result in immune suppression and telomere elongation, and 2) the alternate alleles that decrease enhancer activity, lead to de-differentiation and inhibition of apoptosis. Notably, the eSNPs tend to disrupt the binding of known prostate transcription factors including FOX, AR and HOX families. Lastly, the identified eSNPs can be combined into a polygenic risk score that adds value to current GWAS-based risk variants in assessing PrCa risk in independent cohorts.</p>
},
	issn = {2693-5015},
	doi = {10.21203/rs.3.rs-5485172/v1},
	author = {Hannenhalli, Sridhar and Li, Shan and Fatema, Kaniz and Nidharshan, Sundarraj and Singh, Arashdeep and Rajagopal, Padma Sheila and Notani, Dimple and Takeda, David}
}
@article {94676,
	title = {A global-scale screening of non-native aquatic organisms to identify potentially invasive species under current and future climate conditions.},
	journal = {Sci Total Environ},
	volume = {788},
	year = {2021},
	month = {2021 Sep 20},
	pages = {147868},
	abstract = {<p>The threat posed by invasive non-native species worldwide requires a global approach to identify which introduced species are likely to pose an elevated risk of impact to native species and ecosystems. To inform policy, stakeholders and management decisions on global threats to aquatic ecosystems, 195 assessors representing 120 risk assessment areas across all six inhabited continents screened 819 non-native species from 15 groups of aquatic organisms (freshwater, brackish, marine plants and animals) using the Aquatic Species Invasiveness Screening Kit. This multi-lingual decision-support tool for the risk screening of aquatic organisms provides assessors with risk scores for a species under current and future climate change conditions that, following a statistically based calibration, permits the accurate classification of species into high-, medium- and low-risk categories under current and predicted climate conditions. The 1730 screenings undertaken encompassed wide geographical areas (regions, political entities, parts thereof, water bodies, river basins, lake drainage basins, and marine regions), which permitted thresholds to be identified for almost all aquatic organismal groups screened as well as for tropical, temperate and continental climate classes, and for tropical and temperate marine ecoregions. In total, 33 species were identified as posing a {\textquoteright}very high risk{\textquoteright} of being or becoming invasive, and the scores of several of these species under current climate increased under future climate conditions, primarily due to their wide thermal tolerances. The risk thresholds determined for taxonomic groups and climate zones provide a basis against which area-specific or climate-based calibrated thresholds may be interpreted. In turn, the risk rankings help decision-makers identify which species require an immediate {\textquoteright}rapid{\textquoteright} management action (e.g. eradication, control) to avoid or mitigate adverse impacts, which require a full risk assessment, and which are to be restricted or banned with regard to importation and/or sale as ornamental or aquarium/fishery enhancement.</p>
},
	issn = {1879-1026},
	doi = {10.1016/j.scitotenv.2021.147868},
	author = {Vilizzi, Lorenzo and Copp, Gordon H and Hill, Jeffrey E and Adamovich, Boris and Aislabie, Luke and Akin, Daniel and Al-Faisal, Abbas J and Almeida, David and Azmai, M N Amal and Bakiu, Rigers and Bellati, Adriana and Bernier, Ren{\'e}e and Bies, Jason M and Bilge, G{\"o}k{\c c}en and Branco, Paulo and Bui, Thuyet D and Canning-Clode, Jo{\~a}o and Cardoso Ramos, Henrique Anatole and Castellanos-Galindo, Gustavo A and Castro, Nuno and Chaichana, Ratcha and Chainho, Paula and Chan, Joleen and Cunico, Almir M and Curd, Amelia and Dangchana, Punyanuch and Dashinov, Dimitriy and Davison, Phil I and de Camargo, Mariele P and Dodd, Jennifer A and Durland Donahou, Allison L and Edsman, Lennart and Ekmek{\c c}i, F G{\"u}ler and Elphinstone-Davis, Jessica and Er{\H o}s, Tibor and Evangelista, Charlotte and Fenwick, Gemma and Ferincz, {\'A}rp{\'a}d and Ferreira, Teresa and Feunteun, Eric and Filiz, Halit and Forneck, Sandra C and Gajduchenko, Helen S and Gama Monteiro, Jo{\~a}o and Gestoso, Ignacio and Giannetto, Daniela and Gilles, Allan S and Gizzi, Francesca and Glamuzina, Branko and Glamuzina, Luka and Goldsmit, Jesica and Gollasch, Stephan and Goulletquer, Philippe and Grabowska, Joanna and Harmer, Rogan and Haubrock, Phillip J and He, Dekui and Hean, Jeffrey W and Herczeg, G{\'a}bor and Howland, Kimberly L and {\.I}lhan, Ali and Interesova, Elena and Jakub{\v c}inov{\'a}, Katar{\'\i}na and Jelmert, Anders and Johnsen, Stein I and Kakareko, Tomasz and Kanongdate, Kamalaporn and Killi, Nur{\c c}in and Kim, Jeong-Eun and K{\i}rankaya, {\c S}erife G{\"u}ls{\"u}n and K{\v n}azovick{\'a}, Dominika and Kopeck{\'y}, Old{\v r}ich and Kostov, Vasil and Koutsikos, Nicholas and Kozic, Sebastian and Kuljanishvili, Tatia and Kumar, Biju and Kumar, Lohith and Kurita, Yoshihisa and Kurtul, Irmak and Lazzaro, Lorenzo and Lee, Laura and Lehtiniemi, Maiju and Leonardi, Giovanni and Leuven, Rob S E W and Li, Shan and Lipinskaya, Tatsiana and Liu, Fei and Lloyd, Lance and Lorenzoni, Massimo and Luna, Sergio Alberto and Lyons, Timothy J and Magellan, Kit and Malmstr{\o}m, Martin and Marchini, Agnese and Marr, Sean M and Masson, G{\'e}rard and Masson, Laurence and McKenzie, Cynthia H and Memedemin, Daniyar and Mendoza, Roberto and Minchin, Dan and Miossec, Laurence and Moghaddas, Seyed Daryoush and Moshobane, Moleseng C and Mumladze, Levan and Naddafi, Rahmat and Najafi-Majd, Elnaz and N{\u a}stase, Aurel and N{\u a}vodaru, Ion and Neal, J Wesley and Nienhuis, Sarah and Nimtim, Matura and Nolan, Emma T and Occhipinti-Ambrogi, Anna and Ojaveer, Henn and Olenin, Sergej and Olsson, Karin and Onikura, Norio and O{\textquoteright}Shaughnessy, Kathryn and Paganelli, Daniele and Parretti, Paola and Patoka, Ji{\v r}{\'\i} and Pavia, Richard Thomas B and Pellitteri-Rosa, Daniele and Pelletier-Rousseau, Mich{\`e}le and Peralta, Elfritzson M and Perdikaris, Costas and Pietraszewski, Dariusz and Piria, Marina and Pitois, Sophie and Pompei, Laura and Poulet, Nicolas and Preda, Cristina and Puntila-Dodd, Riikka and Qashqaei, Ali T and Rado{\v c}aj, Tena and Rahmani, Hossein and Raj, Smrithy and Reeves, David and Ristovska, Milica and Rizevsky, Viktor and Robertson, D Ross and Robertson, Peter and Ruykys, Laura and Saba, Abdulwakil O and Santos, Jos{\'e} M and Sar{\i}, Hasan M and Segurado, Pedro and Semenchenko, Vitaliy and Senanan, Wansuk and Simard, Nathalie and Simonovi{\'c}, Predrag and Sk{\'o}ra, Micha{\l} E and Slov{\'a}k {\v S}vol{\'\i}kov{\'a}, Krist{\'\i}na and Smeti, Evangelia and {\v S}m{\'\i}dov{\'a}, Tereza and {\v S}peli{\'c}, Ivan and Srebaliene, Greta and Stasolla, Gianluca and Stebbing, Paul and {\v S}tevove, Barbora and Suresh, Vettath R and Szajbert, Bettina and Ta, Kieu Anh T and Tarkan, Ali Serhan and Tempesti, Jonathan and Therriault, Thomas W and Tidbury, Hannah J and Top-Karaku{\c s}, Nildeniz and Tricarico, Elena and Troca, D{\'e}bora F A and Tsiamis, Konstantinos and Tuckett, Quenton M and Tutman, Pero and Uyan, Umut and Uzunova, Eliza and Vardakas, Leonidas and Velle, Gaute and Verreycken, Hugo and Vintsek, Lizaveta and Wei, Hui and Weiperth, Andr{\'a}s and Weyl, Olaf L F and Winter, Emily R and W{\l}odarczyk, Rados{\l}aw and Wood, Louisa E and Yang, Ruibin and Yap{\i}c{\i}, Sercan and Yeo, Shayne S B and Yo{\u g}urt{\c c}uo{\u g}lu, Baran and Yunnie, Anna L E and Zhu, Yunjie and Zi{\k e}ba, Grzegorz and {\v Z}it{\v n}anov{\'a}, Krist{\'\i}na and Clarke, Stacey}
}
