
@article {30982,
	title = {Identification of a Single Pair of Interneurons for Bitter Taste Processing in the Drosophila Brain.},
	journal = {Curr Biol},
	year = {2018},
	month = {2018 Feb 21},
	abstract = {<p>Drosophila has become an excellent model system for investigating the organization and function of the gustatory system due to the relatively simple neuroanatomical organization of its brain and the availability of powerful genetic and transgenic technology. Thus, at the molecular and cellular levels, a great deal of insight into the peripheral detection and coding of gustatory information has already been attained. In contrast, much less is known about the central neural circuits that process this information and induce behaviorally appropriate motor output. Here, we combine functional behavioral tests with targeted transgene expression through specific driver lines to identify a single bilaterally homologous pair of bitter-sensitive interneurons that are located in the subesophageal zone of the brain. Anatomical and functional data indicate that these interneurons receive specific synaptic input from bitter-sensitive gustatory receptor neurons. Targeted transgenic activation and inactivation experiments show that these bitter-sensitive interneurons can largely suppress the proboscis extension reflex to appetitive stimuli, such as sugar and water. These functional experiments, together with calcium-imaging studies and calcium-modulated photoactivatable ratiometric integrator (CaMPARI) labeling, indicate that these first-order local interneurons play an important role in the inhibition of the proboscis extension reflex that occurs in response to bitter tastants. Taken together, our studies present a cellular identification and functional characterization of a key gustatory interneuron in the bitter-sensitive gustatory circuitry of the adult fly.</p>
},
	issn = {1879-0445},
	doi = {10.1016/j.cub.2018.01.084},
	author = {Bohra, Ali Asgar and Kallman, Benjamin R and Reichert, Heinrich and VijayRaghavan, K}
}
@article {25252,
	title = {Identification and functional characterization of muscle satellite cells in Drosophila.},
	journal = {Elife},
	volume = {6},
	year = {2017},
	month = {2017 Oct 26},
	abstract = {<p>Work on genetic model systems such as Drosophila and mouse has shown that the fundamental mechanisms of myogenesis are remarkably similar in vertebrates and invertebrates. Strikingly however, satellite cells, the adult muscle stem cells that are essential for the regeneration of damaged muscles in vertebrates, have not been reported in invertebrates. In this study we show that lineal descendants of muscle stem cells are present in adult muscle of Drosophila as small, unfused cells observed at the surface and in close proximity to the mature muscle fibers. Normally quiescent, following muscle fiber injury, we show that these cells express Zfh1 and engage in Notch-Delta dependent proliferative activity and generate lineal descendant populations, which fuse with the injured muscle fiber. In view of strikingly similar morphological and functional features, we consider these novel cells to be the Drosophila equivalent of vertebrate muscle satellite cells.</p>
},
	issn = {2050-084X},
	doi = {10.7554/eLife.30107},
	author = {Chaturvedi, Dhananjay and Reichert, Heinrich and Gunage, Rajesh D and VijayRaghavan, K}
}
