
@article {82362,
	title = {Sarcopterygian fin ontogeny elucidates the origin of hands with digits.},
	journal = {Sci Adv},
	volume = {6},
	year = {2020},
	month = {2020 Aug},
	pages = {eabc3510},
	abstract = {<p>How the hand and digits originated from fish fins during the Devonian fin-to-limb transition remains unsolved. Controversy in this conundrum stems from the scarcity of ontogenetic data from extant lobe-finned fishes. We report the patterning of an autopod-like domain by during fin development of the Australian lungfish, the most closely related extant fish relative of tetrapods. Differences from tetrapod limbs include the absence of digit-specific expansion of and and distal limitation of and , which potentially evolved through an enhanced response to signaling in limbs. These developmental patterns indicate that the digit program originated in postaxial fin radials and later expanded anteriorly inside of a preexisting autopod-like domain during the evolution of limbs. Our findings provide a genetic framework for the transition of fins into limbs that supports the significance of classical models proposing a bending of the tetrapod metapterygial axis.</p>
},
	issn = {2375-2548},
	doi = {10.1126/sciadv.abc3510},
	author = {Woltering, Joost M and Irisarri, Iker and Ericsson, Rolf and Joss, Jean M P and Sordino, Paolo and Meyer, Axel}
}
