
@article {80781,
	title = {The bacterial quorum sensing signal DSF hijacks  sterol biosynthesis to suppress plant innate immunity.},
	journal = {Life Sci Alliance},
	volume = {3},
	year = {2020},
	month = {2020 Oct},
	abstract = {<p>Quorum sensing (QS) is a recognized phenomenon that is crucial for regulating population-related behaviors in bacteria. However, the direct specific effect of QS molecules on host biology is largely understudied. In this work, we show that the QS molecule DSF (-11-methyl-dodecenoic acid) produced by pv. can suppress pathogen-associated molecular pattern-triggered immunity (PTI) in , mediated by flagellin-induced activation of flagellin receptor FLS2. The DSF-mediated attenuation of innate immunity results from the alteration of FLS2 nanoclusters and endocytic internalization of plasma membrane FLS2. DSF altered the lipid profile of , with a particular increase in the phytosterol species, which impairs the general endocytosis pathway mediated by clathrin and FLS2 nano-clustering on the plasma membrane. The DSF effect on receptor dynamics and host immune responses could be entirely reversed by sterol removal. Together, our results highlighted the importance of sterol homeostasis to plasma membrane organization and demonstrate a novel mechanism by which pathogenic bacteria use their communicating molecule to manipulate pathogen-associated molecular pattern-triggered host immunity.</p>
},
	issn = {2575-1077},
	doi = {10.26508/lsa.202000720},
	author = {Tran, Tuan Minh and Ma, Zhiming and Triebl, Alexander and Nath, Sangeeta and Cheng, Yingying and Gong, Ben-Qiang and Han, Xiao and Wang, Junqi and Li, Jian-Feng and Wenk, Markus R and Torta, Federico and Mayor, Satyajit and Yang, Liang and Miao, Yansong}
}
