
@article {93672,
	title = {Adult neural stem cells have latent inflammatory potential that is kept suppressed by  to facilitate adult neurogenesis.},
	journal = {Sci Adv},
	volume = {7},
	year = {2021},
	month = {2021 May},
	abstract = {<p>Inflammation is known to adversely affect adult neurogenesis, wherein the source of inflammation is largely thought to be extraneous to the neurogenic niche. Here, we demonstrate that the adult hippocampal neural progenitors harbor an inflammatory potential that is proactively suppressed by transcription factor 4 (). Deletion of in hippocampal -expressing progenitors causes loss of proliferative capacity and acquisition of myeloid inflammatory properties. This transformation abolishes their differentiation potential and causes production of detrimental factors that adversely affect niche cells, causing inflammation in the dentate gyrus. Thus, on one hand, deletion causes abrogation of proliferative progenitors leading to reduction of adult neurogenesis, while on the other, their accompanying inflammatory transformation inflicts inflammation in the niche. Taken together, we provide the first evidence for a latent inflammatory potential of adult hippocampal neural progenitors and identify as a critical regulator that facilitates adult neurogenesis via proactive suppression of this detrimental potential.</p>
},
	issn = {2375-2548},
	doi = {10.1126/sciadv.abf5606},
	author = {Shariq, Mohammad and Sahasrabuddhe, Vinaya and Krishna, Sreevatsan and Radha, Swathi and Bellampalli, Ravishankara and Dwivedi, Anukriti and Cheramangalam, Rajit and Reizis, Boris and H{\'e}bert, Jean and Ghosh, Hiyaa S}
}
@article {62766,
	title = {Adult Neurogenesis and the Promise of Adult Neural Stem Cells.},
	journal = {J Exp Neurosci},
	volume = {13},
	year = {2019},
	month = {2019},
	pages = {1179069519856876},
	abstract = {<p>The adult brain, even though largely postmitotic, is now known to have dividing cells that can make both glia and neurons. Of these, the precursor cells that have the potential to make new neurons in the adult brain have attracted great attention from researchers, anticipating their therapeutic potential for neurodegenerative conditions. In this review, I will focus on adult neurogenesis, from the perspective of the overall neurogenic potential in the adult brain, current understanding of the {\textquoteright}adult neural stem cell{\textquoteright}, and the importance of as a decisive factor for neurogenesis under homeostasis and pathologic conditions.</p>
},
	issn = {1179-0695},
	doi = {10.1177/1179069519856876},
	author = {Ghosh, Hiyaa S}
}
