
@article {152586,
	title = {Confronting risks of mirror life.},
	journal = {Science},
	volume = {386},
	year = {2024},
	month = {2024 Dec 20},
	pages = {1351-1353},
	abstract = {<p>Broad discussion is needed to chart a path forward.</p>
},
	keywords = {Artificial Life, Bacteria, Biosecurity, Risk, Stereoisomerism},
	issn = {1095-9203},
	doi = {10.1126/science.ads9158},
	author = {Adamala, Katarzyna P and Agashe, Deepa and Belkaid, Yasmine and Bittencourt, Daniela Matias de C and Cai, Yizhi and Chang, Matthew W and Chen, Irene A and Church, George M and Cooper, Vaughn S and Davis, Mark M and Devaraj, Neal K and Endy, Drew and Esvelt, Kevin M and Glass, John I and Hand, Timothy W and Inglesby, Thomas V and Isaacs, Farren J and James, Wilmot G and Jones, Jonathan D G and Kay, Michael S and Lenski, Richard E and Liu, Chenli and Medzhitov, Ruslan and Nicotra, Matthew L and Oehm, Sebastian B and Pannu, Jaspreet and Relman, David A and Schwille, Petra and Smith, James A and Suga, Hiroaki and Szostak, Jack W and Talbot, Nicholas J and Tiedje, James M and Venter, J Craig and Winter, Gregory and Zhang, Weiwen and Zhu, Xinguang and Zuber, Maria T}
}
@article {54874,
	title = {Evolthon: A community endeavor to evolve lab evolution.},
	journal = {PLoS Biol},
	volume = {17},
	year = {2019},
	month = {2019 Mar},
	pages = {e3000182},
	abstract = {<p>In experimental evolution, scientists evolve organisms in the lab, typically by challenging them to new environmental conditions. How best to evolve a desired trait? Should the challenge be applied abruptly, gradually, periodically, sporadically? Should one apply chemical mutagenesis, and do strains with high innate mutation rate evolve faster? What are ideal population sizes of evolving populations? There are endless strategies, beyond those that can be exposed by individual labs. We therefore arranged a community challenge, Evolthon, in which students and scientists from different labs were asked to evolve Escherichia coli or Saccharomyces cerevisiae for an abiotic stress-low temperature. About 30 participants from around the world explored diverse environmental and genetic regimes of evolution. After a period of evolution in each lab, all strains of each species were competed with one another. In yeast, the most successful strategies were those that used mating, underscoring the importance of sex in evolution. In bacteria, the fittest strain used a strategy based on exploration of different mutation rates. Different strategies displayed variable levels of performance and stability across additional challenges and conditions. This study therefore uncovers principles of effective experimental evolutionary regimens and might prove useful also for biotechnological developments of new strains and for understanding natural strategies in evolutionary arms races between species. Evolthon constitutes a model for community-based scientific exploration that encourages creativity and cooperation.</p>
},
	issn = {1545-7885},
	doi = {10.1371/journal.pbio.3000182},
	author = {Kaminski Strauss, Sivan and Schirman, Dvir and Jona, Ghil and Brooks, Aaron N and Kunjapur, Aditya M and Nguyen Ba, Alex N and Flint, Alice and Solt, Andras and Mershin, Andreas and Dixit, Atray and Yona, Avihu H and Cs{\"o}rg{\H o}, B{\'a}lint and Busby, Bede Phillip and Hennig, Bianca P and P{\'a}l, Csaba and Schraivogel, Daniel and Schultz, Daniel and Wernick, David G and Agashe, Deepa and Levi, Dikla and Zabezhinsky, Dmitry and Russ, Dor and Sass, Ehud and Tamar, Einat and Herz, Elad and Levy, Emmanuel D and Church, George M and Yelin, Idan and Nachman, Iftach and Gerst, Jeffrey E and Georgeson, Joseph M and Adamala, Katarzyna P and Steinmetz, Lars M and R{\"u}bsam, Marc and Ralser, Markus and Klutstein, Michael and Desai, Michael M and Walunjkar, Nilima and Yin, Ning and Aharon Hefetz, Noa and Jakimo, Noah and Snitser, Olga and Adini, Omri and Kumar, Prashant and Soo Hoo Smith, Rachel and Zeidan, Razi and Hazan, Ronen and Rak, Roni and Kishony, Roy and Johnson, Shannon and Nouriel, Shira and Vonesch, Sibylle C and Foster, Simmie and Dagan, Tal and Wein, Tanita and Karydis, Thrasyvoulos and Wannier, Timothy M and Stiles, Timothy and Olin-Sandoval, Viridiana and Mueller, William F and Bar-On, Yinon M and Dahan, Orna and Pilpel, Yitzhak}
}
