
@article {49144,
	title = {5-HT deletion protects against Clozapine-induced hyperglycemia.},
	journal = {J Pharmacol Sci},
	volume = {139},
	year = {2019},
	month = {2018 Dec 18},
	pages = {133-135},
	abstract = {<p>Clozapine is an antipsychotic known for its superior efficacy in treating drug-resistant Schizophrenia. However, Clozapine induces various side effects such as hyperglycemia, agranulocytosis, weight gain etc. The mechanisms of these Clozapine-induced side effects have remained largely elusive though an important role is ascribed to 5-HT (Serotonin receptor subtype-2A). In this pilot study, we report for the first time that the 5-HT {\textquoteright}global{\textquoteright} knockout mice (Htr2a) are resistant to the Clozapine-induced hyperglycemia. Importantly though, the Htr2a mice exhibit near normal basal glucose metabolism in the glucose tolerance tests. Collectively, the Htr2a mice provide an important tool to study the Clozapine-induced hyperglycemia.</p>
},
	issn = {1347-8648},
	doi = {10.1016/j.jphs.2018.11.015},
	author = {Joshi, Radhika Sudhir and Singh, Shishu Pal and Panicker, Mitradas M}
}
