
@article {97224,
	title = {Gjd2b-mediated gap junctions promote glutamatergic synapse formation and dendritic elaboration in Purkinje neurons.},
	journal = {Elife},
	volume = {10},
	year = {2021},
	month = {2021 Aug 04},
	abstract = {<p>Gap junctions between neurons serve as electrical synapses, in addition to conducting metabolites and signaling molecules. During development, early-appearing gap junctions are thought to prefigure chemical synapses, which appear much later. We present evidence for this idea at a central, glutamatergic synapse and provide some mechanistic insights. Loss or reduction in the levels of the gap junction protein Gjd2b decreased the frequency of glutamatergic miniature excitatory postsynaptic currents (mEPSCs) in cerebellar Purkinje neurons (PNs) in larval zebrafish. Ultrastructural analysis in the molecular layer showed decreased synapse density. Further, mEPSCs had faster kinetics and larger amplitudes in mutant PNs, consistent with their stunted dendritic arbors. Time-lapse microscopy in wild type and mutant PNs reveals that Gjd2b puncta promote the elongation of branches and that CaMKII may be a critical mediator of this process. These results demonstrate that Gjd2b-mediated gap junctions regulate glutamatergic synapse formation and dendritic elaboration in PNs.</p>
},
	issn = {2050-084X},
	doi = {10.7554/eLife.68124},
	author = {Sitaraman, Sahana and Yadav, Gnaneshwar and Agarwal, Vandana and Jabeen, Shaista and Verma, Shivangi and Jadhav, Meha and Thirumalai, Vatsala}
}
@article {43855,
	title = {The interplay between electrical and chemical synaptogenesis.},
	journal = {J Neurophysiol},
	year = {2018},
	month = {2018 Aug 01},
	abstract = {<p>Neurons communicate with each other via electrical or chemical synaptic connections. The pattern and strength of connections between neurons is critical for generating appropriate output. What mechanisms govern the formation of electrical and/or chemical synapses between two neurons? Recent studies indicate that common molecular players could regulate the formation of both these classes of synapses. In addition, electrical and chemical synapses can mutually co-regulate each other{\textquoteright}s formation. Electrical activity, generated spontaneously by the nervous system, or initiated from sensory experience, plays an important role in this process, leading to the selection of appropriate connections and the elimination of inappropriate ones. In this review, we discuss recent studies that shed light on the formation and developmental interactions of chemical and electrical synapses.</p>
},
	issn = {1522-1598},
	doi = {10.1152/jn.00398.2018},
	author = {Jabeen, Shaista and Thirumalai, Vatsala}
}
