
@article {28250,
	title = {Two new substituted polychiral 5, 6-dihydro-alpha-pyrones from Orthosiphon diffusus and molecular docking studies},
	journal = {PHYTOCHEMISTRY LETTERS},
	volume = {22},
	year = {2017},
	month = {12/2017},
	pages = { 21-26},
	abstract = {<p>Chemical investigation on Orthosiphon diffusus lead to isolation of two new substituted polychiral 5, 6-dihydro-alpha-pyrones, orthodiffenes E-F (5-6) which were characterized from the detailed studies of their 1D and 2D NMR spectra. Isolated molecules orthodiffenes E-F (5-6) along with previously isolated, reported orthodiffene A-D (14) molecules were subjected to in silico studies and analysed for anticancer target Topoisomerse I-B - DNA complex. Orthodiffene D and E are giving noteworthy observations while all isolated molecules are showing a pattern of binding in active pocket similar to each other however, different from Camptothecin, an anticancer agent. Orthodiffene A-C have comparable cytotoxicity to Camptothecin, which we have earlier reported.</p>
},
	doi = {10.1016/j.phytol.2017.08.006},
	author = {Holla, Harish and Sharma, Akanksha and Bhat, Pritesh and Shinde, Dhananjay and Das, Biswanath}
}
