
@article {115034,
	title = {Progressing Towards a Human-Centric Approach in Cancer Research.},
	journal = {Front Oncol},
	volume = {12},
	year = {2022},
	month = {2022},
	pages = {896633},
	abstract = {<p>Despite the advancement in research methodologies and technologies for cancer research, there is a high rate of anti-cancer drug attrition. In this review, we discuss different conventional and modern approaches in cancer research and how human-centric models can improve on the voids conferred by more traditional animal-centric models, thereby offering a more reliable platform for drug discovery. Advanced three-dimensional cell culture methodologies, along with computational analysis form the core of human-centric cancer research. This can provide a holistic understanding of the research problems and help design specific and accurate experiments that could lead to the development of better cancer therapeutics. Here, we propose a new human-centric research roadmap that promises to provide a better platform for cancer research and drug discovery.</p>
},
	issn = {2234-943X},
	doi = {10.3389/fonc.2022.896633},
	author = {Parekh, Aditya and Das, Subhayan and Das, Chandan K and Mandal, Mahitosh}
}
