
@article {911,
	title = {Maturation of a central brain flight circuit in Drosophila requires Fz2/Ca{\texttwosuperior}$^{+}$ signaling.},
	journal = {Elife},
	volume = {4},
	year = {2015},
	month = {2015},
	abstract = {<p>The final identity of a differentiated neuron is determined by multiple signaling events, including activity dependent calcium transients. Non-canonical Frizzled2 (Fz2) signaling generates calcium transients that determine neuronal polarity, neuronal migration, and synapse assembly in the developing vertebrate brain. Here, we demonstrate a requirement for Fz2/Ca(2+) signaling in determining the final differentiated state of a set of central brain dopaminergic neurons in Drosophila, referred to as the protocerebral anterior medial (PAM) cluster. Knockdown or inhibition of Fz2/Ca(2+) signaling during maturation of the flight circuit in pupae reduces Tyrosine Hydroxylase (TH) expression in the PAM neurons and affects maintenance of flight. Thus, we demonstrate that Fz2/Ca(2+) transients during development serve as a pre-requisite for normal adult behavior. Our results support a neural mechanism where PAM neuron send projections to the α{\textquoteright} and β{\textquoteright} lobes of a higher brain centre, the mushroom body, and function in dopaminergic re-inforcement of flight.</p>
},
	issn = {2050-084X},
	doi = {10.7554/eLife.07046},
	author = {Agrawal, Tarjani and Hasan, Gaiti}
}
